• Gene id: 91179

Gene Summary

• Gene Symbol: SCARF2   Gene   UCSC   Ensembl
• Aliases: NSR1, SREC-II, SREC2, SRECRP-1, VDEGS
• Gene name: scavenger receptor class F member 2
• Alternate names: scavenger receptor class F member 2, scavenger receptor expressed by endothelial cells 2 protein,
• Gene location: 22q11.21 (20437824: 20424583)     Exons: 11     NC_000022.11
• Gene summary(Entrez): The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low densi
• OMIM: 606808

Protein Summary

• Protein general information: Q96GP6  
  • Name: Scavenger receptor class F member 2 (SRECRP 1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC II)
  • Length: 871  
  • Mass: 92384
  • Tissue specificity: Predominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary. {ECO
• Sequence:

  MEGAGPRGAGPARRRGAGGPPSPLLPSLLLLLLLWMLPDTVAPQELNPRGRNVCRAPGSQVPTCCAGWRQQGDEC
  GIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGA
  RCEHACQCQHGTCHPRSGACRCEPGWWGAQCASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQ
  SGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEG
  RCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFV
  CADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCDPVTGACHLETNQRKGVMGAGALL
  VLLVCLLLSLLGCCCACRGKDPTRRPRPRRELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLD
  NTLNCSFLEPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPAS
  AEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPPPPDPATKPKVSWIHG
  KHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPRTRDPTPRPPGLPEEATALAAPSPPRARARG
  RGPGLLEPTDAGGPPRSAPEAASMLAAELRGKTRSLGRAEVALGAQGPREKPAPPQKAKRSVPPASPARAPPATE
  TPGPEKAATDLPAPETPRKKTPIQKPPRKKSREAAGELGRAGAPTL

• Structural information:
  • Protein Domains: (71..11-)
    (/note="EGF-like-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (122..15-)
    (/note="EGF-like-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (148..18-)
    (/note="EGF-like-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:-)
  • Interpro: IPR013032  IPR000742  IPR009030  IPR002049  IPR033327   IPR042635  
  • Prosite: PS00022 PS01186 PS50026
  • STRING: ENSP00000477564
• Other Databases: GeneCards:  SCARF2  Malacards:  SCARF2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA	biological process
GO:0005044	scavenger receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA	biological process
GO:0005044	scavenger receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0006897	endocytosis	IEA	biological process
GO:0005925	focal adhesion	HDA	cellular component

Diseases

Associated diseases	References
Van den Ende-Gupta syndrome	KEGG:H01886
Van den Ende-Gupta syndrome	KEGG:H01886
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq