• Gene id: 90806

Gene Summary

• Gene Symbol: ANGEL2   Gene   UCSC   Ensembl
• Aliases: Ccr4d, KIAA0759L
• Gene name: angel homolog 2
• Alternate names: protein angel homolog 2,
• Gene location: 1q32.3 (75784770: 75825798)     Exons: 21     NC_000017.11

Protein Summary

• Protein general information: Q5VTE6  
  • Name: Protein angel homolog 2
  • Length: 544  
  • Mass: 62339
• Sequence:

  MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFS
  LNWRPPCLFESRTQFQYCNWRPDNLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILG
  DKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDH
  YGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPYAA
  CPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLP
  IGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFS
  LSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLWTVNGLP
  NENNSSDHLPLLAKFRLEL

• Structural information:
  • Interpro: IPR036691  IPR005135  
  • STRING: ENSP00000355929
• Other Databases: GeneCards:  ANGEL2  Malacards:  ANGEL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000175	3'-5'-exoribonuclease activity	IBA	molecular function
GO:0003730	mRNA 3'-UTR binding	IBA	molecular function
GO:0070935	3'-UTR-mediated mRNA stabilization	IBA	biological process
GO:0003730	mRNA 3'-UTR binding	IDA	molecular function
GO:0045930	negative regulation of mitotic cell cycle	IMP	biological process
GO:0070935	3'-UTR-mediated mRNA stabilization	IMP	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0015030	Cajal body	IDA	cellular component
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881