• Gene id: 89953

Gene Summary

• Gene Symbol: KLC4   Gene   UCSC   Ensembl
• Aliases: KNSL8, bA387M24.3
• Gene name: kinesin light chain 4
• Alternate names: kinesin light chain 4, kinesin-like protein 8,
• Gene location: 6p21.1 (43059593: 43075098)     Exons: 18     NC_000006.12
• OMIM: 0

Protein Summary

• Protein general information: Q9NSK0  
  • Name: Kinesin light chain 4 (KLC 4) (Kinesin like protein 8)
  • Length: 619  
  • Mass: 68,640
• Sequence:

  MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHEEGLVHEKARQLRRSM
  ENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLRDELAGTQQRLQRSEQAVAQLEEEKKHLEFL
  GQLRQYDEDGHTSEEKEGDATKDSLDDLFPNEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQG
  RYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNN
  LAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDN
  PNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGGTPYAEYG
  GWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGD
  SVKFEGGEDASVAVEWSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAA
  PLQVSRGLSASTMDLSSSS

• Structural information:
  • Interpro: IPR002151  IPR015792  IPR013026  IPR011990  IPR019734  
  • Prosite: PS01160 PS50005 PS50293
  • STRING: ENSP00000259708
• Other Databases: GeneCards:  KLC4  Malacards:  KLC4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003777	microtubule motor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005871	kinesin complex	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0003777	microtubule motor activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005871	kinesin complex	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05132	Salmonella infection

Diseases

Associated diseases	References
Male factor infertility	MIK: 22182811
Oligozoospermia	MIK: 22182811
Azoospermia	MIK: 22182811
Azoospermia	MIK: 22182811
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
22182811	Azoospermia				Male infertility	Lactoferrin Prostatic acid phosphatase Human Zinc-Alpha-2-Glycoprotein Prostate specific antigen Progestagen-associated endometrial protein Kinesin light chain 4 Kinesin light chain 4 Prolactin inducible protein Izumo sperm-egg fusion protein 1
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq