• Gene id: 89849

Gene Summary

• Gene Symbol: ATG16L2   Gene   UCSC   Ensembl
• Aliases: ATG16B, WDR80
• Gene name: autophagy related 16 like 2
• Alternate names: autophagy-related protein 16-2, APG16-like 2, ATG16 autophagy related 16-like 2, WD repeat-containing protein 80,
• Gene location: 11q13.4 (72814406: 72845131)     Exons: 1     NC_000011.10
• OMIM: 618716

Protein Summary

• Protein general information: Q8NAA4  
  • Name: Autophagy related protein 16 2 (APG16 like 2) (WD repeat containing protein 80)
  • Length: 619  
  • Mass: 68998
• Sequence:

  MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEE
  SELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALEARVAQLREARAQQA
  QQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQEL
  KKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKR
  RGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQT
  LEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWD
  LGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNT
  LKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWC
  YSGSHMVSVDQGRKVVLWQ

• Structural information:
  • Interpro: IPR013923  IPR020472  IPR015943  IPR001680  IPR019775   IPR017986  IPR036322  
  • Prosite: PS00678 PS50082 PS50294
  • STRING: ENSP00000326340
• Other Databases: GeneCards:  ATG16L2  Malacards:  ATG16L2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000045	autophagosome assembly	IBA	biological process
GO:0000421	autophagosome membrane	IBA	cellular component
GO:0039689	negative stranded viral RNA replication	IBA	biological process
GO:0005829	cytosol	ISS	cellular component
GO:0006914	autophagy	ISS	NOT|biological process
GO:0005776	autophagosome	ISS	NOT|cellular component
GO:0000045	autophagosome assembly	ISS	NOT|biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0039689	negative stranded viral RNA replication	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04140	Autophagy - animal

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)