• Gene id: 8872

Gene Summary

• Gene Symbol: CDC123   Gene   UCSC   Ensembl
• Aliases: C10orf7, D123
• Gene name: cell division cycle 123
• Alternate names: cell division cycle protein 123 homolog, HT-1080, PZ32, cell division cycle 123 homolog,
• Gene location: 10p14-p13 (54357905: 54382034)     Exons: 9     NC_000018.10
• OMIM: 617708

Protein Summary

• Protein general information: O75794  
  • Name: Cell division cycle protein 123 homolog (Protein D123) (HT 1080) (PZ32)
  • Length: 336  
  • Mass: 39135
  • Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis. {ECO
• Sequence:

  MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDSDDEAEEIQWSDDENT
  ATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIH
  CTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKF
  LDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSP
  YLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD

• Structural information:
  • Interpro: IPR009772  
  • STRING: ENSP00000281141
• Other Databases: GeneCards:  CDC123  Malacards:  CDC123

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0051301	cell division	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0007050	cell cycle arrest	TAS	biological process
GO:0008284	positive regulation of cell population proliferation	TAS	biological process
GO:1905143	eukaryotic translation initiation factor 2 complex assembly	ISS	biological process
GO:0045948	positive regulation of translational initiation	ISS	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881