• Gene id: 8722

Gene Summary

• Gene Symbol: CTSF   Gene   UCSC   Ensembl
• Aliases: CATSF, CLN13
• Gene name: cathepsin F
• Alternate names: cathepsin F,
• Gene location: 11q13.2 (66568605: 66563462)     Exons: 14     NC_000011.10
• Gene summary(Entrez): Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (
• OMIM: 603539

Protein Summary

• Protein general information: Q9UBX1  
  • Name: Cathepsin F (CATSF) (EC 3.4.22.41)
  • Length: 484  
  • Mass: 53366
  • Tissue specificity: High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.
• Sequence:

  MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQG
  SLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISS
  LSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALD
  RGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
  TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKV
  YINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIK
  NSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD

• Structural information:
  • Interpro: IPR038765  IPR000169  IPR025660  IPR000668  IPR039417   IPR013201  
  • Prosite: PS00139 PS00639
  • CDD: cd02248
  • PDB: 1D5U 1M6D
  • PDBsum: 1D5U 1M6D
  • STRING: ENSP00000310832
• Other Databases: GeneCards:  CTSF  Malacards:  CTSF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051603	proteolysis involved in cellular protein catabolic process	IBA	biological process
GO:0005764	lysosome	IBA	cellular component
GO:0005615	extracellular space	IBA	cellular component
GO:0004197	cysteine-type endopeptidase activity	IBA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0004197	cysteine-type endopeptidase activity	TAS	molecular function
GO:0005764	lysosome	TAS	cellular component
GO:0006508	proteolysis	TAS	biological process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	biological process
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0043202	lysosomal lumen	TAS	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:1903561	extracellular vesicle	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04142	Lysosome
hsa04210	Apoptosis

Diseases

Associated diseases	References
Neuronal ceroid lipofuscinosis	KEGG:H00149
Kufs disease	KEGG:H02276
Neuronal ceroid lipofuscinosis	KEGG:H00149
Kufs disease	KEGG:H02276
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)