• Gene id: 8526

Gene Summary

• Gene Symbol: DGKE   Gene   UCSC   Ensembl
• Aliases: AHUS7, DAGK5, DAGK6, DGK, NPHS7
• Gene name: diacylglycerol kinase epsilon
• Alternate names: diacylglycerol kinase epsilon, DAG kinase epsilon, DGK-epsilon, diacylglycerol kinase, epsilon 64kDa, diglyceride kinase epsilon,
• Gene location: 17q22 (56834130: 56869566)     Exons: 14     NC_000017.11
• Gene summary(Entrez): Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidony
• OMIM: 601440

Protein Summary

• Protein general information: P52429  
  • Name: Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK epsilon)
  • Length: 567  
  • Mass: 63927
  • Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level). {ECO
• Sequence:

  MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKHGWRDTDLFSQPTYCC
  VCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVLDAMPHHWIRGNVPLCSYCMVCKQQCGCQPK
  LCDYRCIWCQKTVHDECMKNSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILAN
  SRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEK
  YIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFS
  VGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGIIVLNIG
  YWGGGCRLWEGMGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPW
  AQGPCTVTITHKTHAMMLYFSGEQTDDDISSTSDQEDIKATE

• Structural information:
  • Protein Domains: (215..35-)
    (/note="DAGKc-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00783"-)
  • Interpro: IPR017438  IPR037607  IPR000756  IPR001206  IPR016064   IPR002219  
  • Prosite: PS50146 PS00479 PS50081
  • CDD: cd00029
  • STRING: ENSP00000284061
• Other Databases: GeneCards:  DGKE  Malacards:  DGKE

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0046339	diacylglycerol metabolic process	IBA	biological process
GO:0046486	glycerolipid metabolic process	IBA	biological process
GO:0046834	lipid phosphorylation	IBA	biological process
GO:0004143	diacylglycerol kinase activity	IBA	molecular function
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0003951	NAD+ kinase activity	IEA	molecular function
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0030168	platelet activation	TAS	biological process
GO:0050804	modulation of chemical synaptic transmission	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0016301	kinase activity	IDA	molecular function
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0046486	glycerolipid metabolic process	IEA	biological process
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04072	Phospholipase D signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa00564	Glycerophospholipid metabolism
hsa05231	Choline metabolism in cancer
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Nephrotic syndrome	KEGG:H01657
Membranoproliferative glomerulonephritis	KEGG:H01726
Nephrotic syndrome	KEGG:H01657
Membranoproliferative glomerulonephritis	KEGG:H01726
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)