• Gene id: 84953

Gene Summary

• Gene Symbol: MICALCL   Gene   UCSC   Ensembl
• Aliases: Ebitein1
• Gene name: MICAL C-terminal like
• Alternate names: MICAL C-terminal-like protein, ERK2-binding testicular protein 1, ebitein-1, mical-cL,
• Gene location: 11p15.3 (12286899: 12362139)     Exons: 9     NC_000011.10
• OMIM: 612355

Protein Summary

• Protein general information: Q6ZW33  
  • Name: MICAL C terminal like protein (Mical cL) (ERK2 binding testicular protein 1) (Ebitein 1)
  • Length: 695  
  • Mass: 77277
• Sequence:

  MSPPKDPSPSLPLPSSSSHSSSPPSSSSTSVSGNAPDGSSPPQMTASEPLSQVSRGHPSPPTPNFRRRAVAQGAP
  REIPLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLA
  GEDREKGSTGARKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERISQKSAENGRGGRVLK
  PVRPLLLPRAAGEPLPTQRGAQEKMGTPAEQAQGERNVPPPKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQES
  KTLPAQACTRSFSLRKTNSNKDGDQHSPGRNQSSAFSPPDPALRTHSLPNRPSKVFPALRSPPCSKIEDVPTLLE
  KVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKDIRDLFGSPKRKVLPEDSAQALEKLLQPFKST
  SLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKL
  EKAMKQLVKQEELKRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDEAQLLQEWFKLVLEKNKL
  MRYESELLIMAQELELEDHQSRLEQKLREKMLKEESQKDEKDLNEEQEVFTELMQVIEQRDKLVDSLEEQRIREK
  AEDQHFESFVFSRGCQLSRT

• Structural information:
  • Protein Domains: (534..68-)
    (/note="bMERB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01195"-)
  • Interpro: IPR022735  IPR016103  
  • Prosite: PS51848
  • PDB: 5SZH 5SZI 5SZJ 5SZK
  • PDBsum: 5SZH 5SZI 5SZJ 5SZK
  • STRING: ENSP00000256186
• Other Databases: GeneCards:  MICALCL  Malacards:  MICALCL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030036	actin cytoskeleton organization	IBA	biological process
GO:0051019	mitogen-activated protein kinase binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0005815	microtubule organizing center	IBA	cellular component
GO:0031941	filamentous actin	IBA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0051019	mitogen-activated protein kinase binding	ISS	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)