• Gene id: 84926

Gene Summary

• Gene Symbol: SPRYD3   Gene   UCSC   Ensembl
• Gene name: SPRY domain containing 3
• Alternate names: SPRY domain-containing protein 3,
• Gene location: 12q13.13 (53079389: 53064315)     Exons: 11     NC_000012.12

Protein Summary

• Protein general information: Q8NCJ5  
  • Name: SPRY domain containing protein 3
  • Length: 442  
  • Mass: 49694
• Sequence:

  MRRTRRPRFVLMNKMDDLNLHYRFLNWRRRIREIREVRAFRYQERFKHILVDGDTLSYHGNSGEVGCYVASRPLT
  KDSNYFEVSIVDSGVRGTIAVGLVPQYYSLDHQPGWLPDSVAYHADDGKLYNGRAKGRQFGSKCNSGDRIGCGIE
  PVSFDVQTAQIFFTKNGKRVGSTIMPMSPDGLFPAVGMHSLGEEVRLHLNAELGREDDSVMMVDSYEDEWGRLHD
  VRVCGTLLEYLGKGKSIVDVGLAQARHPLSTRSHYFEVEIVDPGEKCYIALGLARKDYPKNRHPGWSRGSVAYHA
  DDGKIFHGSGVGDPFGPRCYKGDIMGCGIMFPRDYILDSEGDSDDSCDTVILSPTARAVRNVRNVMYLHQEGEEE
  EEEEEEEEDGEEIEPEHEGRKVVVFFTRNGKIIGKKDAVVPSGGFFPTIGMLSCGEKVKVDLHPLSG

• Structural information:
  • Protein Domains: (17..20-)
    (/note="B30.2/SPRY-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00548"-)
  • Interpro: IPR001870  IPR013320  IPR003877  IPR035783  
  • Prosite: PS50188
  • CDD: cd12908
  • PDB: 2YYO
  • PDBsum: 2YYO
  • STRING: ENSP00000301463
• Other Databases: GeneCards:  SPRYD3  Malacards:  SPRYD3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0007166	cell surface receptor signaling pathway	IBA	biological process
GO:0008536	Ran GTPase binding	IBA	molecular function
GO:0007010	cytoskeleton organization	IBA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray