• Gene id: 84513

Gene Summary

• Gene Symbol: PLPP5   Gene   UCSC   Ensembl
• Aliases: DPPL1, HTPAP, PPAPDC1B
• Gene name: phospholipid phosphatase 5
• Alternate names: phospholipid phosphatase 5, diacylglycerol pyrophosphate like 1, diacylglycerol pyrophosphate phosphatase-like 1, phosphatidate phosphatase PPAPDC1B, phosphatidic acid phosphatase type 2 domain containing 1B, phosphatidic acid phosphatase type 2 domain-contain,
• Gene location: 8p11.23 (38269434: 38261789)     Exons: 1     NC_000008.11
• OMIM: 610626

Protein Summary

• Protein general information: Q8NEB5  
  • Name: Phospholipid phosphatase 5 (EC 3.1.3.4) (EC 3.1.3.81) (Phosphatidic acid phosphatase type 2 domain containing protein 1B)
  • Length: 264  
  • Mass: 29484
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLA
  KFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPS
  GHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAY
  VCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI

• Structural information:
  • Interpro: IPR036938  IPR000326  IPR028668  
  • STRING: ENSP00000392553
• Other Databases: GeneCards:  PLPP5  Malacards:  PLPP5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008195	phosphatidate phosphatase activity	IBA	molecular function
GO:0007165	signal transduction	IBA	biological process
GO:0006644	phospholipid metabolic process	IBA	biological process
GO:0046839	phospholipid dephosphorylation	IBA	biological process
GO:0016791	phosphatase activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0000810	diacylglycerol diphosphate phosphatase activity	IDA	molecular function
GO:0006644	phospholipid metabolic process	IEA	biological process
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0046839	phospholipid dephosphorylation	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0000810	diacylglycerol diphosphate phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0006644	phospholipid metabolic process	IEA	biological process
GO:0046839	phospholipid dephosphorylation	IDA	biological process
GO:0008195	phosphatidate phosphatase activity	IDA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005737	cytoplasm	TAS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00564	Glycerophospholipid metabolism
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)