• Gene id: 8450

Gene Summary

• Gene Symbol: CUL4B   Gene   UCSC   Ensembl
• Aliases: CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
• Gene name: cullin 4B
• Alternate names: cullin-4B,
• Gene location: Xq24 (120575828: 120524588)     Exons: 24     NC_000087.7
• Gene summary(Entrez): This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and
• OMIM: 300304

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa05170	Human immunodeficiency virus 1 infection
hsa04120	Ubiquitin mediated proteolysis
hsa05170	Human immunodeficiency virus 1 infection
hsa03420	Nucleotide excision repair

Diseases

Associated diseases	References
Male factor infertility	MIK: 26832838
Spermatogenesis defects	MIK: 26846852
Syndromic X-linked mental retardation	KEGG: H00658
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 26846852
Male infertility	MIK: 26846852
Post-meiotic sperm morphogenesis	MIK: 26832838
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
26846852	Important for Spermatogenesis, Male infertility				Male infertility
26832838	Post-meiotic sperm morphogenesis, Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881