• Gene id: 84076

Gene Summary

• Gene Symbol: TKTL2   Gene   UCSC   Ensembl
• Gene name: transketolase like 2
• Alternate names: transketolase-like protein 2, testis tissue sperm-binding protein Li 39a,
• Gene location: 4q32.2 (163473753: 163471094)     Exons: 1     NC_000004.12

Protein Summary

• Protein general information: Q9H0I9  
  • Name: Transketolase like protein 2 (EC 2.2.1.1)
  • Length: 626  
  • Mass: 67877
  • Tissue specificity: Overexpressed in hepatoma cancer cells. {ECO
• Sequence:

  MMANDAKPDVKTVQVLRDTANRLRIHSIRATCASGSGQLTSCCSAAEVVSVLFFHTMKYKQTDPEHPDNDRFILS
  RGHAAPILYAAWVEVGDISESDLLNLRKLHSDLERHPTPRLPFVDVATGSLGQGLGTACGMAYTGKYLDKASYRV
  FCLMGDGESSEGSVWEAFAFASHYNLDNLVAVFDVNRLGQSGPAPLEHGADIYQNCCEAFGWNTYLVDGHDVEAL
  CQAFWQASQVKNKPTAIVAKTFKGRGIPNIEDAENWHGKPVPKERADAIVKLIESQIQTNENLIPKSPVEDSPQI
  SITDIKMTSPPAYKVGDKIATQKTYGLALAKLGRANERVIVLSGDTMNSTFSEIFRKEHPERFIECIIAEQNMVS
  VALGCATRGRTIAFAGAFAAFFTRAFDQLRMGAISQANINLIGSHCGVSTGEDGVSQMALEDLAMFRSIPNCTVF
  YPSDAISTEHAIYLAANTKGMCFIRTSQPETAVIYTPQENFEIGQAKVVRHGVNDKVTVIGAGVTLHEALEAADH
  LSQQGISVRVIDPFTIKPLDAATIISSAKATGGRVITVEDHYREGGIGEAVCAAVSREPDILVHQLAVSGVPQRG
  KTSELLDMFGISTRHIIAAVTLTLMK

• Structural information:
  • Interpro: IPR029061  IPR009014  IPR005475  IPR033248  IPR005474  
  • CDD: cd02012
  • STRING: ENSP00000280605
• Other Databases: GeneCards:  TKTL2  Malacards:  TKTL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030976	thiamine pyrophosphate binding	IBA	molecular function
GO:0004802	transketolase activity	IBA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004802	transketolase activity	IEA	molecular function
GO:0005737	cytoplasm	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa01230	Biosynthesis of amino acids
hsa00030	Pentose phosphate pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881