• Gene id: 84074

Gene Summary

• Gene Symbol: QRICH2   Gene   UCSC   Ensembl
• Aliases: SPGF35
• Gene name: glutamine rich 2
• Alternate names: glutamine-rich protein 2,
• Gene location: 17q25.1 (76308810: 76271295)     Exons: 21     NC_000017.11
• OMIM: 618304

Protein Summary

• Protein general information: Q9H0J4  
  • Name: Glutamine rich protein 2
  • Length: 1663  
  • Mass: 180827
  • Tissue specificity: Expressed in the sperm. {ECO
• Sequence:

  MKDAAEELSFARVLLQRVDELEKLFKDREQFLELVSRKLSLVPGAEEVTMVTWEELEQAITDGWRASQAGSETLM
  GFSKHGGFTSLTSPEGTLSGDSTKQPSIEQALDSASGLGPDRTASGSGGTAHPSDGVSSREQSKVPSGTGRQQQP
  RARDEAGVPRLHQSSTFQFKSDSDRHRSREKLTSTQPRRNARPGPVQQDLPLARDQPSSVPASQSQVHLRPDRRG
  LEPTGMNQPGLVPASTYPHGVVPLSMGQLGVPPPEMDDRELIPFVVDEQRMLPPSVPGRDQQGLELPSTDQHGLV
  SVSAYQHGMTFPGTDQRSMEPLGMDQRGCVISGMGQQGLVPPGIDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLM
  PISADQQGFVQPSLEATGFIQPGTEQHDLIQSGRFQRALVQRGAYQPGLVQPGADQRGLVRPGMDQSGLAQPGAD
  QRGLVWPGMDQSGLAQPGRDQHGLIQPGTGQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQRALVQPGAYQPGLV
  QPGADQIDVVQPGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQRGLAQPRADHQRGLVPPGADQRGLVQPGA
  DQHGLVQPGVDQHGLAQPGEVQRSLVQPGIVQRGLVQPGAVQRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGL
  VQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQPGADQPGLVQPGAGQLGMVQPGI
  GQQGMVQPQADPHGLVQPGAYPLGLVQPGAYLHDLSQSGTYPRGLVQPGMDQYGLRQPGAYQPGLIAPGTKLRGS
  STFQADSTGFISVRPYQHGMVPPGREQYGQVSPLLASQGLASPGIDRRSLVPPETYQQGLMHPGTDQHSPIPLST
  GLGSTHPDQQHVASPGPGEHDQVYPDAAQHGHAFSLFDSHDSMYPGYRGPGYLSADQHGQEGLDPNRTRASDRHG
  IPAQKAPGQDVTLFRSPDSVDRVLSEGSEVSSEVLSERRNSLRRMSSSFPTAVETFHLMGELSSLYVGLKESMKD
  LDEEQAGQTDLEKIQFLLAQMVKRTIPPELQEQLKTVKTLAKEVWQEKAKVERLQRILEGEGNQEAGKELKAGEL
  RLQLGVLRVTVADIEKELAELRESQDRGKAAMENSVSEASLYLQDQLDKLRMIIESMLTSSSTLLSMSMAPHKAH
  TLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKKAKLQRQDEELLGRVQSAILQVQGDCE
  KLNITTSNLIEDHRQKQKDIAMLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDATTEQLNHMMQE
  LVAKMSGQEQDWQKMLDRLLTEMDNKLDRLELDPVKQLLEDRWKSLRQQLRERPPLYQADEAAAMRRQLLAHFHC
  LSCDRPLETPVTGHAIPVTPAGPGLPGHHSIRPYTVFELEQVRQHSRNLKLGSAFPRGDLAQMEQSVGRLRSMHS
  KMLMNIEKVQIHFGGSTKASSQIIRELLHAQCLGSPCYKRVTDMADYTYSTVPRRCGGSHTLTYPYHRSRPQHLP
  RGLYPTEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILRKDSSGTSKRKSQQPRPHVHRPPSLSSNGQLPSRP
  QSAQISAGNTSER

• Structural information:
  • Interpro: IPR032013  
  • DIP: 50256
  • STRING: ENSP00000262765
• Other Databases: GeneCards:  QRICH2  Malacards:  QRICH2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0036126	sperm flagellum	IDA	cellular component
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IMP	biological process
GO:0030031	cell projection assembly	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0030317	flagellated sperm motility	IMP	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0031965	nuclear membrane	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic failure	KEGG:H01282
Spermatogenic failure	KEGG:H01282
Cryptorchidism	MIK: 28606200
Multiple morphological anomalies of the sperm flagella (MMAF syndrome)	MIK: 31292949
Male infertility	MIK: 31292949
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31292949	Multiple morphological anomalies of the sperm flagella (MMAF syndrome), Male infertility	c.3501C>G [p.Tyr1167Ter] and c.4614C>G [p.Tyr1538Ter], c.4855+4_4855+7delAGTG, c.4119G>A p.Met1373Ile, c.3587C>T p.Pro1196Leu, c.3433G>A p.Glu1145Lys, c.3278A>G p.Glu1093Gly, c.3081A>G p.Ala1027Ala, c.290_291delTC p.Ser97TyrfsTer7, c.4618C>T p.Arg1540Tr	Chinese , North Africa , Iran, and Eu rope	169 (2 families), 167 MMAF-affected subjects	Male infertility	NGS
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray