• Gene id: 83939

Gene Summary

• Gene Symbol: EIF2A   Gene   UCSC   Ensembl
• Aliases: CDA02, EIF-2A, MST089, MSTP004, MSTP089
• Gene name: eukaryotic translation initiation factor 2A
• Alternate names: eukaryotic translation initiation factor 2A, 65 kDa eukaryotic translation initiation factor 2A, eukaryotic translation initiation factor 2A, 65kDa,
• Gene location: 3q25.1 (150546677: 150586015)     Exons: 14     NC_000003.12
• Gene summary(Entrez): This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be co
• OMIM: 609234

Protein Summary

• Protein general information: Q9BY44  
  • Name: Eukaryotic translation initiation factor 2A (eIF 2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N terminally processed]
  • Length: 585  
  • Mass: 64990
  • Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. {ECO
• Sequence:

  MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTNKGLLHSFDL
  LKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQNWCPSWSEDETLCARNVNNEV
  HFFENNNFNTIANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVT
  MLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKAT
  IFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTA
  TCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPA
  LRNKPITNSKLHEEEPPQNMKPQSGNDKPLSKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQ
  SISGDPEIDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI

• Structural information:
  • Interpro: IPR011387  IPR013979  IPR015943  IPR036322  
  • DIP: 40272
  • STRING: ENSP00000417229
• Other Databases: GeneCards:  EIF2A  Malacards:  EIF2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000049	tRNA binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0043022	ribosome binding	IBA	molecular function
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0006417	regulation of translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0006413	translational initiation	IEA	biological process
GO:0032933	SREBP signaling pathway	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:1990928	response to amino acid starvation	IEA	biological process
GO:0009967	positive regulation of signal transduction	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0045296	cadherin binding	HDA	molecular function
GO:0005850	eukaryotic translation initiation factor 2 complex	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0042255	ribosome assembly	IMP	biological process
GO:0005615	extracellular space	HDA	cellular component
GO:0072562	blood microparticle	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0043022	ribosome binding	IMP	molecular function
GO:0006417	regulation of translation	IMP	biological process
GO:0003743	translation initiation factor activity	IMP	molecular function
GO:0000049	tRNA binding	IMP	molecular function

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray