• Gene id: 83891

Gene Summary

• Gene Symbol: SNX25   Gene   UCSC   Ensembl
• Aliases: MSTP043, SBBI31
• Gene name: sorting nexin 25
• Alternate names: sorting nexin-25,
• Gene location: 4q35.1 (185204236: 185368019)     Exons: 26     NC_000004.12
• OMIM: 606041

Protein Summary

• Protein general information: Q9H3E2  
  • Name: Sorting nexin 25
  • Length: 840  
  • Mass: 97945
• Sequence:

  MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVDVVKVVCNDVVRTLLTHFCDLK
  AANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPD
  YINQMLLAQLAYREQMNEHHKRAYTYAPSYEDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGK
  ETAAMKADLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKILQFEDILANTFYREH
  FGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKI
  QEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVNKLRE
  LNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGEVTEENGE
  QLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNK
  FLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEETEEDSDLSDYGDDVD
  GRKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWIFSEQMLVYYINIFRDAFWPNG
  KLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVGQQNARHGIIKIFNALQETRANKHLLYALMELLLIELC
  PELRVHLDQLKAGQV

• Structural information:
  • Protein Domains: (1..16-)
    (/note="PXA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00147,-ECO:0000255|PROSITE-ProRule:PRU00553)
    (287..40-)
    (/note="RGS-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00171-)
    (508..62-)
    (/note="PX-)
    (/evidence="ECO:0000255|P-)
  • Interpro: IPR001683  IPR003114  IPR036871  IPR016137  IPR036305   IPR034905  IPR037899  IPR013937  
  • Prosite: PS50195 PS51207 PS50132
  • CDD: cd06878
  • PDB: 5WOE
  • PDBsum: 5WOE
  • STRING: ENSP00000426255
• Other Databases: GeneCards:  SNX25  Malacards:  SNX25

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IEA	biological process
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0005768	endosome	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0034713	type I transforming growth factor beta receptor binding	IEA	molecular function
GO:0032801	receptor catabolic process	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IEA	biological process
GO:0010008	endosome membrane	IEA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IMP	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0032801	receptor catabolic process	IMP	biological process
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	IMP	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq