• Gene id: 83716

Gene Summary

• Gene Symbol: CRISPLD2   Gene   UCSC   Ensembl
• Aliases: CRISP11, LCRISP2, LGL1
• Gene name: cysteine rich secretory protein LCCL domain containing 2
• Alternate names: cysteine-rich secretory protein LCCL domain-containing 2, CRISP-11, LCCL domain-containing cysteine-rich secretory protein 2, cysteine-rich secretory protein 11, late gestation lung 1, testis secretory sperm-binding protein Li 207a, trypsin inhibitor,
• Gene location: 16q24.1 (84819980: 84909509)     Exons: 16     NC_000016.10

Protein Summary

• Protein general information: Q9H0B8  
  • Name: Cysteine rich secretory protein LCCL domain containing 2 (Cysteine rich secretory protein 11) (CRISP 11) (LCCL domain containing cysteine rich secretory protein 2)
  • Length: 497  
  • Mass: 55920
• Sequence:

  MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS
  NMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWC
  PERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSY
  GGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKG
  STCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKP
  SSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVIS
  NESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ

• Structural information:
  • Protein Domains: (62..20-)
    (/note="SCP-)
    (284..37-)
    (/note="LCCL-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00123-)
    (385..48-)
    (/note="LCCL-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00123"-)
  • Interpro: IPR018244  IPR014044  IPR035940  IPR001283  IPR004043   IPR036609  
  • Prosite: PS01010 PS50820
  • STRING: ENSP00000262424
• Other Databases: GeneCards:  CRISPLD2  Malacards:  CRISPLD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0005539	glycosaminoglycan binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0030133	transport vesicle	IDA	cellular component
GO:0030198	extracellular matrix organization	IEA	biological process
GO:0008201	heparin binding	IEA	molecular function
GO:0005539	glycosaminoglycan binding	IEA	molecular function
GO:0030324	lung development	IEA	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0060325	face morphogenesis	IMP	biological process
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq