• Gene id: 81928

Gene Summary

• Gene Symbol: CABLES2   Gene   UCSC   Ensembl
• Aliases: C20orf150, dJ908M14.2, ik3-2
• Gene name: Cdk5 and Abl enzyme substrate 2
• Alternate names: CDK5 and ABL1 enzyme substrate 2, interactor with CDK3 2,
• Gene location: 20q13.33 (62407282: 62388629)     Exons: 10     NC_000020.11
• OMIM: 618772

Protein Summary

• Protein general information: Q9BTV7  
  • Name: CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3 2)
  • Length: 478  
  • Mass: 52235
• Sequence:

  MAAAAAGGAPGPAPGPAGPPPPAAPTSAARAPPQALRRRGDSRRRQAALFFLNNISLDGRPPSLGPGGEKPPPPP
  AEAREPPAPPPPEPPTGLPARTPAPQGLLSPTQVPTGLGLDGQRQRKRVTSQRCSLEFLEDAVGCAPAQRTKHTS
  GSPRHKGLKKTHFIKNMRQYDTRNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGGVSVSSEMV
  FELEGVELGADGKVVSYAKFLYPTNALVTHKSDSHGLLPTPRPSVPRTLPGSRHKPAPTKSAPASTELGSDVGDT
  LEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEYVKPSDLKKDMNETFREKFPHVKLTLSKIRSLKREMRSLSEE
  CSLEPVTVAMAYVYFEKLVLQGKLSKQNRKLCAGACVLLAAKISSDLRKSGVTQLIDKLEERFRFNRRDLIGFEF
  TVLVALELALYLPENQVLPHYRRLTQQF

• Structural information:
  • Interpro: IPR012388  IPR013763  IPR036915  IPR006671  
  • CDD: cd00043
  • STRING: ENSP00000279101
• Other Databases: GeneCards:  CABLES2  Malacards:  CABLES2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051726	regulation of cell cycle	IEA	biological process
GO:0051301	cell division	IEA	biological process
GO:0007049	cell cycle	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Non obstructive azoospermia	MIK: 23869807
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq