• Gene id: 81887

Gene Summary

• Gene Symbol: LAS1L   Gene   UCSC   Ensembl
• Aliases: Las1, Las1-like, WTS, dJ475B7.2
• Gene name: LAS1 like ribosome biogenesis factor
• Alternate names: ribosomal biogenesis protein LAS1L, protein LAS1 homolog,
• Gene location: Xq12 (49412205: 49416475)     Exons: 3     NC_000003.12
• OMIM: 300964

Protein Summary

• Protein general information: Q9Y4W2  
  • Name: Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog)
  • Length: 734  
  • Mass: 83065
• Sequence:

  MSWESGAGPGLGSQGMDLVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFCDDHKLQRYALNRITV
  WRSRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKVPLKCLAQEVNIPDW
  IVDLRHELTHKKMPHINDCRRGCYFVLDWLQKTYWCRQLENSLRETWELEEFREGIEEEDQEEDKNIVVDDITEQ
  KPEPQDDGKSTESDVKADGDSKGSEEVDSHCKKALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNP
  SPRVECVLAELKGVTCENREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLNDVLVP
  KPFSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYILRWTVELIVANTKTGRNARRFSAGQWEARRG
  WRLFNCSASLDWPRMVESCLGSPCWASPQLLRIIFKAMGQGLPDEEQEKLLRICSIYTQSGENSLVQEGSEASPI
  GKSPYTLDSLYWSVKPASSSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDD
  EEEDRMEVGPFSTGQESPTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYL
  LDQPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWSQGQLHGLKTGLQLF

• Structural information:
  • Interpro: IPR007174  
  • STRING: ENSP00000363944
• Other Databases: GeneCards:  LAS1L  Malacards:  LAS1L

Diseases

Associated diseases	References
Wilson-Turner syndrome	KEGG:H02267
Wilson-Turner syndrome	KEGG:H02267
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)