• Gene id: 81616

Gene Summary

• Gene Symbol: ACSBG2   Gene   UCSC   Ensembl
• Aliases: BGR, BRGL, PRTD-NY3, PRTDNY3
• Gene name: acyl-CoA synthetase bubblegum family member 2
• Alternate names: long-chain-fatty-acid--CoA ligase ACSBG2, arachidonate--CoA ligase ACSBG2, bubblegum-related protein, testicular tissue protein Li 8,
• Gene location: 19p13.3 (6135632: 6193102)     Exons: 17     NC_000019.10
• OMIM: 614363

Protein Summary

• Protein general information: Q5FVE4  
  • Name: Long chain fatty acid CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl CoA synthetase bubblegum family member 2) (Arachidonate CoA ligase ACSBG2) (EC 6.2.1.15) (Bubblegum related protein) (PRTD NY3)
  • Length: 666  
  • Mass: 74354
  • Tissue specificity: Testis-specific. {ECO
• Sequence:

  MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNG
  KKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITH
  AKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCA
  VLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA
  LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAK
  TLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCK
  NMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVP
  PIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD
  PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH

• Structural information:
  • Interpro: IPR020845  IPR000873  IPR042099  
  • Prosite: PS00455
  • STRING: ENSP00000465589
• Other Databases: GeneCards:  ACSBG2  Malacards:  ACSBG2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016405	CoA-ligase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0004467	long-chain fatty acid-CoA ligase activity	IBA	molecular function
GO:0042759	long-chain fatty acid biosynthetic process	IBA	biological process
GO:0047676	arachidonate-CoA ligase activity	IDA	molecular function
GO:0004467	long-chain fatty acid-CoA ligase activity	IDA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0007283	spermatogenesis	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0016874	ligase activity	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0003996	acyl-CoA ligase activity	IEA	molecular function
GO:0004467	long-chain fatty acid-CoA ligase activity	IEA	molecular function
GO:0102391	decanoate-CoA ligase activity	IEA	molecular function
GO:0047676	arachidonate-CoA ligase activity	IEA	molecular function
GO:0047617	acyl-CoA hydrolase activity	IDA	molecular function
GO:0006631	fatty acid metabolic process	IDA	biological process
GO:0006631	fatty acid metabolic process	IDA	biological process
GO:0005739	mitochondrion	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0004467	long-chain fatty acid-CoA ligase activity	IDA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0004467	long-chain fatty acid-CoA ligase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa03320	PPAR signaling pathway
hsa01212	Fatty acid metabolism
hsa04920	Adipocytokine signaling pathway
hsa00071	Fatty acid degradation
hsa00061	Fatty acid biosynthesis

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)