• Gene id: 81553

Gene Summary

• Gene Symbol: CYRIA   Gene   UCSC   Ensembl
• Aliases: CYRI-A, FAM49A
• Gene name: CYFIP related Rac1 interactor A
• Alternate names: CYFIP-related Rac1 interactor A, protein FAM49A, family with sequence similarity 49 member A,
• Gene location: 2p24.2 (16665833: 16549458)     Exons: 16     NC_000002.12

Protein Summary

• Protein general information: Q9H0Q0  
  • Name: CYFIP related Rac1 interactor A (Protein CYRIA)
  • Length: 323  
  • Mass: 37313
• Sequence:

  MGNLLKVLTREIENYPHFFLDFENAQPTEGEREIWNQISAVLQDSESILADLQAYKGAGPEIRDAIQNPNDIQLQ
  EKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLEREQALAKEFAEILHFTLRFDELKMRNPA
  IQNDFSYYRRTISRNRINNMHLDIENEVNNEMANRMSLFYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLST
  MTSVCKVMLETPEYRSRFTSEETLMFCMRVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLN
  ALRFTTKHLNDESTSKQIRAMLQ

• Structural information:
  • Interpro: IPR009828  IPR039789  
  • STRING: ENSP00000370724
• Other Databases: GeneCards:  CYRIA  Malacards:  CYRIA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030833	regulation of actin filament polymerization	IEA	biological process
GO:0048365	Rac GTPase binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005622	intracellular	IDA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray