• Gene id: 81533

Gene Summary

• Gene Symbol: ITFG1   Gene   UCSC   Ensembl
• Aliases: 2310047C21Rik, CDA08, LNKN-1, TIP
• Gene name: integrin alpha FG-GAP repeat containing 1
• Alternate names: T-cell immunomodulatory protein, LINKIN, integrin-alpha FG-GAP repeat-containing protein 1,
• Gene location: 16q12.1 (47461273: 47154386)     Exons: 19     NC_000016.10
• OMIM: 611803

Protein Summary

• Protein general information: Q8TB96  
  • Name: T cell immunomodulatory protein (Protein TIP) (Integrin alpha FG GAP repeat containing protein 1) (Linkin)
  • Length: 612  
  • Mass: 68108
  • Tissue specificity: Ubiquitously expressed.
• Sequence:

  MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDKQTDLFVLRERNDLIV
  FLADQNAPYFKPKVKVSFKNHSALITSVVPGDYDGDSQMDVLLTYLPKNYAKSELGAVIFWGQNQTLDPNNMTIL
  NRTFQDEPLIMDFNGDLIPDIFGITNESNQPQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTL
  NATTSTFQFEIWENLDGNFSVSTILEKPQNMMVVGQSAFADFDGDGHMDHLLPGCEDKNCQKSTIYLVRSGMKQW
  VPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQAFLLENVPCNNASCE
  EARRMFKVYWELTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYTKNDFAIHTLKNNFEADAYFVKVIVLSGLCS
  NDCPRKITPFGVNQPGPYIMYTTVDANGYLKNGSAGQLSQSAHLALQLPYNVLGLGRSANFLDHLYVGIPRPSGE
  KSIRKQEWTAIIPNSQLIVIPYPHNVPRSWSAKLYLTPSNIVLLTAIALIGVCVFILAIIGILHWQEKKADDREK
  RQEAHRFHFDAM

• Structural information:
  • Interpro: IPR024881  
  • STRING: ENSP00000319918
• Other Databases: GeneCards:  ITFG1  Malacards:  ITFG1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq