• Gene id: 80117

Gene Summary

• Gene Symbol: ARL14   Gene   UCSC   Ensembl
• Aliases: ARF7
• Gene name: ADP ribosylation factor like GTPase 14
• Alternate names: ADP-ribosylation factor-like protein 14, ADP-ribosylation factor 7, ADP-ribosylation factor-like 14,
• Gene location: 3q25.33 (160677159: 160678447)     Exons: 1     NC_000003.12
• OMIM: 614439

Protein Summary

• Protein general information: Q8N4G2  
  • Name: ADP ribosylation factor like protein 14 (ADP ribosylation factor 7)
  • Length: 192  
  • Mass: 21588
  • Tissue specificity: Expressed in immature dendritic cells. {ECO
• Sequence:

  MGSLGSKNPQTKQAQVLLLGLDSAGKSTLLYKLKLAKDITTIPTIGFNVEMIELERNLSLTVWDVGGQEKMRTVW
  GCYCENTDGLVYVVDSTDKQRLEESQRQFEHILKNEHIKNVPVVLLANKQDMPGALTAEDITRMFKVKKLCSDRN
  WYVQPCCALTGEGLAQGFRKLTGFVKSHMKSRGDTLAFFKQN

• Structural information:
  • Interpro: IPR027417  IPR005225  IPR006689  
  • Prosite: PS51417
  • STRING: ENSP00000323847
• Other Databases: GeneCards:  ARL14  Malacards:  ARL14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016192	vesicle-mediated transport	IBA	biological process
GO:0005525	GTP binding	IBA	molecular function
GO:0006886	intracellular protein transport	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray