• Gene id: 80017

Gene Summary

• Gene Symbol: DGLUCY   Gene   UCSC   Ensembl
• Aliases: C14orf159
• Gene name: D-glutamate cyclase
• Alternate names: D-glutamate cyclase, mitochondrial, UPF0317 protein C14orf159, mitochondrial,
• Gene location: 14q32.11 (91060282: 91225395)     Exons: 20     NC_000014.9
• OMIM: 0

Protein Summary

• Protein general information: Q7Z3D6  
  • Name: D glutamate cyclase, mitochondrial (EC 4.2.1.48)
  • Length: 616  
  • Mass: 66437
• Sequence:

  MPFTLHLRSRLPSAIRSLILQKKPNIRNTSSMAGELRPASLVVLPRSLAPAFERFCQVNTGPLPLLGQSEPEKWM
  LPPQGAISETRMGHPQFWKYEFGACTGSLASLEQYSEQLKDMVAFFLGCSFSLEEALEKAGLPRRDPAGHSQTTV
  PCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPVHMGDPELLGIKELSKPAYGDAMVCPPGEVPVFW
  PSPLTSLGAVSSCETPLAFASIPGCTVMTDLKDAKAPPGCLTPERIPEVHHISQDPLHYSIASVSASQKIRELES
  MIGIDPGNRGIGHLLCKDELLKASLSLSHARSVLITTGFPTHFNHEPPEETDGPPGAVALVAFLQALEKEVAIIV
  DQRAWNLHQKIVEDAVEQGVLKTQIPILTYQGGSVEAAQAFLCKNGDPQTPRFDHLVAIERAGRAADGNYYNARK
  MNIKHLVDPIDDLFLAAKKIPGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYA
  LACALYILYSCAVHSQYLRKAVGPSRAPGDQAWTQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHNT
  HAEMIQKLVDVTTAQV

• Structural information:
  • Interpro: IPR009906  IPR017135  IPR025504  IPR038021  
  • STRING: ENSP00000428263
• Other Databases: GeneCards:  DGLUCY  Malacards:  DGLUCY

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006536	glutamate metabolic process	IBA	biological process
GO:0047820	D-glutamate cyclase activity	IBA	molecular function
GO:0047820	D-glutamate cyclase activity	ISS	molecular function
GO:0005759	mitochondrial matrix	ISS	cellular component
GO:0006536	glutamate metabolic process	ISS	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0047820	D-glutamate cyclase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0047820	D-glutamate cyclase activity	IEA	molecular function
GO:0006536	glutamate metabolic process	IEA	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0008150	biological_process	ND	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00471	D-Glutamine and D-glutamate metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Male factor infertility	MIK: 29961538
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq