• Gene id: 79949

Gene Summary

• Gene Symbol: PLEKHS1   Gene   UCSC   Ensembl
• Aliases: C10orf81, HEL185
• Gene name: pleckstrin homology domain containing S1
• Alternate names: pleckstrin homology domain-containing family S member 1, PH domain-containing family S member 1, PH domain-containing protein C10orf81, epididymis luminal protein 185, epididymis secretory sperm binding protein,
• Gene location: 10q25.3 (75717487: 75674123)     Exons: 16     NC_000005.10

Protein Summary

• Protein general information: Q5SXH7  
  • Name: Pleckstrin homology domain containing family S member 1 (PH domain containing family S member 1) (Epididymis luminal protein 185) (hEL185)
  • Length: 462  
  • Mass: 51763
• Sequence:

  MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEV
  GISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTL
  FYSSPLLGPSSTSEAVGSSSPRNGLQDKHLMEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIAS
  SDSGESIETDGPDQVSGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADV
  EAQTTNDQKGSASLTVVQLSILINNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCHG
  DHLLAVNDLKPQSLEEVSLFLTRSIQKEKLKLTIGRIPNSETFHAASCMCPSKCQSAAPSQLDKPRLNRAPKRSP
  AIKKSQQKGARE

• Structural information:
  • Protein Domains: (14..12-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"-)
  • Interpro: IPR011993  IPR001849  IPR042986  
  • Prosite: PS50003
  • STRING: ENSP00000358316
• Other Databases: GeneCards:  PLEKHS1  Malacards:  PLEKHS1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)