• Gene id: 7991

Gene Summary

• Gene Symbol: TUSC3   Gene   UCSC   Ensembl
• Aliases: D8S1992, M33, MRT22, MRT7, MagT2, N33, OST3A, SLC58A2
• Gene name: tumor suppressor candidate 3
• Alternate names: tumor suppressor candidate 3, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3, magnesium uptake/transporter TUSC3, mental retardation, non-syndromic, autosomal recessive, 22, oligosaccharyl transferase subunit TUSC3, oligosaccharyl,
• Gene location: 8p22 (15540086: 15766648)     Exons: 12     NC_000001.11
• Gene summary(Entrez): This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the
• OMIM: 601385

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01100	Metabolic pathways
hsa04141	Protein processing in endoplasmic reticulum
hsa00513	Various types of N-glycan biosynthesis
hsa00510	N-Glycan biosynthesis

Diseases

Associated diseases	References
Mental retardation	KEGG: H00768
Spermatogenesis defects	MIK: 24096664
Inducing sperm differentiation and maturation	MIK: 24096664
Asthma	GAD: 22424883
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24096664	Involved in spermatogenesis in the testis, inducing sperm differentiation and maturation				Male infertility
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R