• Gene id: 79789

Gene Summary

• Gene Symbol: CLMN   Gene   UCSC   Ensembl
• Gene name: calmin
• Alternate names: calmin, calmin (calponin-like, transmembrane), calponin-like transmembrane domain protein,
• Gene location: 14q32.13 (95319907: 95181939)     Exons: 17     NC_000014.9
• OMIM: 611121

Protein Summary

• Protein general information: Q96JQ2  
  • Name: Calmin (Calponin like transmembrane domain protein)
  • Length: 1002  
  • Mass: 111651
  • Tissue specificity: Widely expressed at intermediate level. {ECO
• Sequence:

  MAAHEWDWFQREELIGQISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVL
  SGRNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRN
  SPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKTRKYGVAVQDFAGSWRSGLAFLAVI
  KAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELEAEDIFD
  SDKEVPIESTFVRIKETPSEQESKVFVLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDS
  STEFMHQIIDQVLQGGPGKTSDISEPSPESSILSSRKENGRSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSP
  RVAKESLRQDGHVLAVEVAEEKEQKQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSL
  SPPGENTVMADSFQIKVNLMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAFNKVPSPHETKPDEDAEAFEN
  HAEKLGKRSIKSAHKKKDSPEPQVKMDKHEPHQDSGEEAEGCPSAPEETPVDKKPEVHEKAKRKSTRPHYEEEGE
  DDDLQGVGEELSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDL
  KNEEMDLEEPEGYMPDLDSREEEADGSQSSSSSSVPGESLPSASDQVLYLSRGGVGTTPASEPAPLAPHEDHQQR
  ETKENDPMDSHQSQESPNLENIANPLEENVTKESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSI
  PSRTSHSDSSIYLRRHTHRSSESDHFSYVQLRNAADLDDRRNRILTRKANSSGEAMSLGSHSPQSDSLTQLVQQP
  DMMYFILFLWLLVYCLLLFPQLDVSRL

• Structural information:
  • Protein Domains: (32..13-)
    1 (/note="Calponin-homology-(CH))
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00044-)
    (187..29-)
    2 (/note="Calponin-homology-(CH))
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00044"-)
  • Interpro: IPR001589  IPR001715  IPR036872  
  • Prosite: PS00019 PS00020 PS50021
  • CDD: cd00014
  • STRING: ENSP00000298912
• Other Databases: GeneCards:  CLMN  Malacards:  CLMN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051647	nucleus localization	IBA	biological process
GO:0051015	actin filament binding	IBA	molecular function
GO:0034993	meiotic nuclear membrane microtubule tethering complex	IBA	cellular component
GO:0008285	negative regulation of cell population proliferation	IBA	biological process
GO:0007097	nuclear migration	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005640	nuclear outer membrane	IBA	cellular component
GO:0003779	actin binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0031175	neuron projection development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R