• Gene id: 79736

Gene Summary

• Gene Symbol: TEFM   Gene   UCSC   Ensembl
• Aliases: C17orf42
• Gene name: transcription elongation factor, mitochondrial
• Alternate names: transcription elongation factor, mitochondrial, transcription elongation factor of mitochondria,
• Gene location: 17q11.2 (30907628: 30898982)     Exons: 6     NC_000017.11
• OMIM: 616422

Protein Summary

• Protein general information: Q96QE5  
  • Name: Transcription elongation factor, mitochondrial
  • Length: 360  
  • Mass: 41676
• Sequence:

  MSGSVLFTAGERWRCFLTPSRSSLYWALHNFCCRKKSTTPKKITPNVTFCDENAKEPENALDKLFSSEQQASILH
  VLNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVPLFKYKSTVQVCNSILCPKTGREKRKSPENRF
  LRKLLKPDIERERLKAVNSIISIVFGTRRIAWAHLDRKLTVLDWQQSDRWSLMRGIYSSSVYLEEISSIISKMPK
  ADFYVLEKTGLSIQNSSLFPILLHFHIMEAMLYALLNKTFAQDGQHQVLSMNRNAVGKHFELMIGDSRTSGKELV
  KQFLFDSILKADPRVFFPSDKIVHYRQMFLSTELQRVEELYDSLLQAIAFYELAVFDSQP

• Structural information:
  • Interpro: IPR012337  IPR010994  IPR039150  
  • PDB: 5OL8 5OL9 5OLA
  • PDBsum: 5OL8 5OL9 5OLA
  • STRING: ENSP00000462963
• Other Databases: GeneCards:  TEFM  Malacards:  TEFM

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042645	mitochondrial nucleoid	IDA	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0030337	DNA polymerase processivity factor activity	IDA	molecular function
GO:0008821	crossover junction endodeoxyribonuclease activity	IDA	NOT|molecular function
GO:0005759	mitochondrial matrix	IDA	cellular component
GO:0006390	mitochondrial transcription	IMP	biological process
GO:0006264	mitochondrial DNA replication	IMP	NOT|biological process
GO:0006119	oxidative phosphorylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006392	transcription elongation from mitochondrial promoter	IEA	biological process
GO:0042645	mitochondrial nucleoid	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0042645	mitochondrial nucleoid	IEA	cellular component
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0006259	DNA metabolic process	IEA	biological process
GO:0006259	DNA metabolic process	IEA	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)