• Gene id: 79726

Gene Summary

• Gene Symbol: WDR59   Gene   UCSC   Ensembl
• Aliases: CDW12, FP977, p90-120
• Gene name: WD repeat domain 59
• Alternate names: GATOR complex protein WDR59, CDw12 antigen, WD repeat-containing protein 59,
• Gene location: 16q23.1 (74985145: 74871361)     Exons: 28     NC_000016.10
• OMIM: 609548

Protein Summary

• Protein general information: Q6PJI9  
  • Name: GATOR complex protein WDR59 (WD repeat containing protein 59)
  • Length: 974  
  • Mass: 109793
• Sequence:

  MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAH
  YFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAG
  ASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPR
  KYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDY
  QLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRN
  LLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNNAAPSFQFINP
  TTITSTMKAKLLKILKDTALQKVKRGQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTA
  YGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLY
  SGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQE
  TCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCS
  VFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEE
  LRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGV
  YCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF

• Structural information:
  • Protein Domains: (393..49-)
    (/note="RWD-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00179"-)
  • Interpro: IPR006575  IPR016135  IPR015943  IPR001680  IPR019775   IPR017986  IPR036322  IPR039456  
  • Prosite: PS50908 PS00678 PS50082 PS50294
  • CDD: cd16692
  • STRING: ENSP00000262144
• Other Databases: GeneCards:  WDR59  Malacards:  WDR59

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005765	lysosomal membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005764	lysosome	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0032008	positive regulation of TOR signaling	IMP	biological process
GO:0061700	GATOR2 complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0034198	cellular response to amino acid starvation	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa04150	mTOR signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq