• Gene id: 79716

Gene Summary

• Gene Symbol: NPEPL1   Gene   UCSC   Ensembl
• Aliases: bA261P9.2
• Gene name: aminopeptidase like 1
• Alternate names: probable aminopeptidase NPEPL1,
• Gene location: 20q13.32 (58689130: 58715843)     Exons: 14     NC_000020.11
• OMIM: 617418

Protein Summary

• Protein general information: Q8NDH3  
  • Name: Probable aminopeptidase NPEPL1 (EC 3.4.11. ) (Aminopeptidase like 1)
  • Length: 523  
  • Mass: 55861
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MANVGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYAT
  VAALPCRVSRHNSPSAAHFITRLVRTCLPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVT
  VEFFLVGQDNGPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGF
  GGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAAIKQ
  GFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQ
  GIATGKYHAAVLTNSAEWEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIAS
  HIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDVEEGDLGRDSKRRRLV

• Structural information:
  • Interpro: IPR011356  IPR041417  IPR000819  
  • Prosite: PS00631
  • CDD: cd00433
  • STRING: ENSP00000348395
• Other Databases: GeneCards:  NPEPL1  Malacards:  NPEPL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0019538	protein metabolic process	IEA	biological process
GO:0030145	manganese ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0008235	metalloexopeptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq