• Gene id: 79670

Gene Summary

• Gene Symbol: TUT7   Gene   UCSC   Ensembl
• Aliases: PAPD6, TENT3B, ZCCHC6
• Gene name: terminal uridylyl transferase 7
• Alternate names: terminal uridylyltransferase 7, PAP associated domain containing 6, TUTase 7, zinc finger CCHC domain-containing protein 6, zinc finger CCHC-type containing 6, zinc finger, CCHC domain containing 6,
• Gene location: 9q21.33 (86354496: 86287732)     Exons: 32     NC_000009.12
• OMIM: 601094

Protein Summary

• Protein general information: Q5VYS8  
  • Name: Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain containing protein 6)
  • Length: 1495  
  • Mass: 171229
• Sequence:

  MGDTAKPYFVKRTKDRGTMDDDDFRRGHPQQDYLIIDDHAKGHGSKMEKGLQKKKITPGNYGNTPRKGPCAVSSN
  PYAFKNPIYSQPAWMNDSHKDQSKRWLSDEHTGNSDNWREFKPGPRIPVINRQRKDSFQENEDGYRWQDTRGCRT
  VRRLFHKDLTSLETTSEMEAGSPENKKQRSRPRKPRKTRNEENEQDGDLEGPVIDESVLSTKELLGLQQAEERLK
  RDCIDRLKRRPRNYPTAKYTCRLCDVLIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAID
  KVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNSDVNIDIQFPAIMSQPDVLLLVQEC
  LKNSDSFIDVDADFHARVPVVVCREKQSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSID
  RPEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQDIEKDVVIWEHTDSAAGDTGITKEE
  APRETPIKRGQVSLILDVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIEDPYS
  VKRNVARTLNSQPVFEYILHCLRTTYKYFALPHKITKSSLLKPLNAITCISEHSKEVINHHPDVQTKDDKLKNSV
  LAQGPGATSSAANTCKVQPLTLKETAESFGSPPKEEMGNEHISVHPENSDCIQADVNSDDYKGDKVYHPETGRKN
  EKEKVGRKGKHLLTVDQKRGEHVVCGSTRNNESESTLDLEGFQNPTAKECEGLATLDNKADLDGESTEGTEELED
  SLNHFTHSVQGQTSEMIPSDEEEEDDEEEEEEEEPRLTINQREDEDGMANEDELDNTYTGSGDEDALSEEDDELG
  EAAKYEDVKECGKHVERALLVELNKISLKEENVCEEKNSPVDQSDFFYEFSKLIFTKGKSPTVVCSLCKREGHLK
  KDCPEDFKRIQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKN
  GFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNT
  LALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIYKGEK
  KPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKY
  IVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRIC
  GKIGHFMKDCPMRRKVRRRRDQEDALNQRYPENKEKRSKEDKEIHNKYTEREVSTKEDKPIQCTPQKAKPMRAAA
  DLGREKILRPPVEKWKRQDDKDLREKRCFICGREGHIKKECPQFKGSSGSLSSKYMTQGKASAKRTQQES

• Structural information:
  • Protein Domains: (551..60-)
    (/note="PAP-associated-1)
    (1233..128-)
    (/note="PAP-associated-2")
  • Interpro: IPR003604  IPR002058  IPR002934  IPR001878  IPR036875  
  • Prosite: PS50158 PS00028
  • PDB: 5W0B 5W0M 5W0N 5W0O
  • PDBsum: 5W0B 5W0M 5W0N 5W0O
  • STRING: ENSP00000365130
• Other Databases: GeneCards:  TUT7  Malacards:  TUT7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016779	nucleotidyltransferase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006397	mRNA processing	IBA	biological process
GO:0031054	pre-miRNA processing	IBA	biological process
GO:0050265	RNA uridylyltransferase activity	IBA	molecular function
GO:0071076	RNA 3' uridylation	IBA	biological process
GO:0031123	RNA 3'-end processing	IDA	biological process
GO:0035198	miRNA binding	IDA	molecular function
GO:0070569	uridylyltransferase activity	IDA	molecular function
GO:0010586	miRNA metabolic process	IDA	biological process
GO:0050265	RNA uridylyltransferase activity	IDA	molecular function
GO:0010526	negative regulation of transposition, RNA-mediated	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0071076	RNA 3' uridylation	IDA	biological process
GO:0050265	RNA uridylyltransferase activity	IDA	molecular function
GO:0031054	pre-miRNA processing	IDA	biological process
GO:0050265	RNA uridylyltransferase activity	IDA	molecular function
GO:0001556	oocyte maturation	ISS	biological process
GO:1990074	polyuridylation-dependent mRNA catabolic process	ISS	biological process
GO:0071076	RNA 3' uridylation	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0016779	nucleotidyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0050265	RNA uridylyltransferase activity	IEA	molecular function
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0071044	histone mRNA catabolic process	IMP	NOT|biological process

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R