• Gene id: 79668

Gene Summary

• Gene Symbol: PARP8   Gene   UCSC   Ensembl
• Aliases: ARTD16, pART16
• Gene name: poly(ADP-ribose) polymerase family member 8
• Alternate names: protein mono-ADP-ribosyltransferase PARP8, ADP-ribosyltransferase diphtheria toxin-like 16,
• Gene location: 5q11.1 (50665830: 50846521)     Exons: 32     NC_000005.10
• OMIM: 608960

Protein Summary

• Protein general information: Q8N3A8  
  • Name: Protein mono ADP ribosyltransferase PARP8 (EC 2.4.2. ) (ADP ribosyltransferase diphtheria toxin like 16) (ARTD16) (Poly [ADP ribose] polymerase 8) (PARP 8)
  • Length: 854  
  • Mass: 95871
• Sequence:

  MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDV
  LVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHK
  HPQLEADLSAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVP
  TVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKS
  KSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVTKSHRTFGRSLSSDPRAEQAMTAIKSHKLLNRPCPAAVKSEE
  CLTLKSHRLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNA
  EGRRLSLTSGLIGILTPSSSSSSQLAPNGAKCIPVRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLR
  PTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKK
  NYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSS
  PPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQ
  KVSAKDEPASSSKSSNTSQSQKKGQQSQFLQSRNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDG
  QVGDANINTQEGGIHKEILRVIGNQTATG

• Structural information:
  • Protein Domains: (617..84-)
    (/note="PARP-catalytic)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00397"-)
  • Interpro: IPR012317  
  • Prosite: PS51059
  • STRING: ENSP00000281631
• Other Databases: GeneCards:  PARP8  Malacards:  PARP8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071782	endoplasmic reticulum tubular network	IBA	cellular component
GO:0043539	protein serine/threonine kinase activator activity	IBA	molecular function
GO:0030968	endoplasmic reticulum unfolded protein response	IBA	biological process
GO:0006471	protein ADP-ribosylation	IBA	biological process
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:0019900	kinase binding	IBA	molecular function
GO:0005635	nuclear envelope	IBA	cellular component
GO:0003950	NAD+ ADP-ribosyltransferase activity	IBA	molecular function
GO:0140289	protein mono-ADP-ribosylation	IDA	biological process
GO:1990404	protein ADP-ribosylase activity	IDA	molecular function
GO:0070213	protein auto-ADP-ribosylation	IDA	biological process
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0005622	intracellular	IDA	cellular component
GO:0071902	positive regulation of protein serine/threonine kinase activity	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881