• Gene id: 79658

Gene Summary

• Gene Symbol: ARHGAP10   Gene   UCSC   Ensembl
• Aliases: GRAF2, PS-GAP, PSGAP
• Gene name: Rho GTPase activating protein 10
• Alternate names: rho GTPase-activating protein 10, GTPase regulator associated with focal adhesion kinase 2, graf-related protein 2, rho-type GTPase-activating protein 10,
• Gene location: 4q31.23 (147732062: 148072780)     Exons: 24     NC_000004.12

Protein Summary

• Protein general information: A1A4S6  
  • Name: Rho GTPase activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf related protein 2) (Rho type GTPase activating protein 10)
  • Length: 786  
  • Mass: 89375
  • Tissue specificity: High levels of expression in heart and skeletal muscle. {ECO
• Sequence:

  MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDA
  VTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLN
  LSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYK
  MELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF
  NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSH
  SFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADW
  EVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSK
  QNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS
  KRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWAST
  IPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFE
  IGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL

• Structural information:
  • Protein Domains: (7..26-)
    (/note="BAR-)
    (265..37-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (389..57-)
    (/note="Rho-GAP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00172-)
    (728..78-)
    (/note="SH3-)
    (/evidence="ECO:0000255|PROS-)
  • Interpro: IPR027267  IPR035486  IPR035485  IPR011993  IPR001849   IPR008936  IPR000198  IPR036028  IPR001452  
  • Prosite: PS50003 PS50238 PS50002
  • CDD: cd12065
  • PDB: 2MIO
  • PDBsum: 2MIO
  • STRING: ENSP00000336923
• Other Databases: GeneCards:  ARHGAP10  Malacards:  ARHGAP10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043066	negative regulation of apoptotic process	IBA	biological process
GO:0007010	cytoskeleton organization	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0005096	GTPase activator activity	IBA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0007010	cytoskeleton organization	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05100	Bacterial invasion of epithelial cells

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq