|
Gene id |
79068 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
FTO Gene UCSC Ensembl |
|
Aliases |
ALKBH9, BMIQ14, GDFD |
|
Gene name |
FTO alpha-ketoglutarate dependent dioxygenase |
|
Alternate names |
alpha-ketoglutarate-dependent dioxygenase FTO, AlkB homolog 9, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, fat mass and obesity associated, fat mass and obesity-associated prote, |
|
Gene location |
16q12.2 (53703962: 54121940) Exons: 16 NC_000016.10
|
|
Gene summary(Entrez) |
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damag
|
|
OMIM |
610966 |
|
| Associated diseases |
References |
| Cancer | GAD: 19726594 |
| Atherosclerosis | GAD: 18550552 |
| Hyperandrogenism | GAD: 19913856 |
| Hyperandrogenism | INFBASE: 19913856 |
| Inflammation | GAD: 19906786 |
| Obesity | GAD: 19828706 |
| Insulin resistance | GAD: 18984658 |
| Metabolic syndrome | GAD: 18339204 |
| Obesity | GAD: 17434869 |
| Diabetes | KEGG: H00409 |
| Diabetes | GAD: 18372903 |
| Anorexia nervosa | GAD: 19746409 |
| Fertilizing defects | GAD: 19265514 |
| Polycystic ovary syndrome (PCOS) | INFBASE: 25592819 |
| Male factor infertility | MIK: 26820768 |
| Cryptorchidism | MIK: 28606200 |
| Male infertility | MIK: 26820768 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 26820768 |
Male infer
tility
|
p.Ser256Asn |
|
77 infertile me
n
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|