• Gene id: 7866

Gene Summary

• Gene Symbol: IFRD2   Gene   UCSC   Ensembl
• Aliases: IFNRP, SKMc15, SM15
• Gene name: interferon related developmental regulator 2
• Alternate names: interferon-related developmental regulator 2, interferon-related protein,
• Gene location: 3p21.31 (50292594: 50287731)     Exons: 12     NC_000003.12
• OMIM: 602725

Protein Summary

• Protein general information: Q12894  
  • Name: Interferon related developmental regulator 2 (Protein SKMC15)
  • Length: 506  
  • Mass: 54814
  • Tissue specificity: Expressed in a variety of tissues.
• Sequence:

  MAWNSPSRRPVWQGGAPREDGGARGVWLPSSGQVSAQRTGRRLVGLEPTPTGSLTPRPPRPVPGMPRARKGNTLR
  KGGQRRGGGARSSAQADSGSSDDEAASEARSTASECPSLLSTTAEDSLGGDVVDEQGQQEDLEEKLKEYVDCLTD
  KSAKTRQGALESLRLALASRLLPDFLLERRLTLADALEKCLKKGKGEEQALAAAVLGLLCVQLGPGPKGEELFHS
  LQPLLVSVLSDSTASPAARLHCASALGLGCYVAAADIQDLVSCLACLESVFSRFYGLGGSSTSPVVPASLHGLLS
  AALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNLRIAAGETIALLFELARDLEEEFVYEDMEALCSVLR
  TLATDSNKYRAKADRRRQRSTFRAVLHSVEGGECEEEIVRFGFEVLYMDSWARHRIYAAFKEVLGSGMHHHLQNN
  ELLRDIFGLGPVLLLDATALKACKVPRFEKHLYNAAAFKARTKARSRVRDKRADIL

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR039777  IPR006921  IPR007701  
  • STRING: ENSP00000392316
• Other Databases: GeneCards:  IFRD2  Malacards:  IFRD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0003674	molecular_function	ND	molecular function
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881