• Gene id: 7798

Gene Summary

• Gene Symbol: LUZP1   Gene   UCSC   Ensembl
• Aliases: LUZP
• Gene name: leucine zipper protein 1
• Alternate names: leucine zipper protein 1,
• Gene location: 1p36.12 (23177807: 23084022)     Exons: 7     NC_000001.11
• Gene summary(Entrez): This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec
• OMIM: 608525

Protein Summary

• Protein general information: Q86V48  
  • Name: Leucine zipper protein 1
  • Length: 1076  
  • Mass: 120275
• Sequence:

  MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI
  EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK
  ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMN
  RDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT
  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTK
  FRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKK
  TEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLG
  RADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP
  VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVN
  TTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREAL
  RSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQ
  VGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR
  WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGT
  RRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMEEEGEDCTLSVYRQLHNSLDPSELPG
  KQGLPESGRVRAEERLRPTRPCAEEN

• Structural information:
  • Interpro: IPR026734  
  • DIP: 33113
  • STRING: ENSP00000303758
• Other Databases: GeneCards:  LUZP1  Malacards:  LUZP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0021503	neural fold bending	IBA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0060840	artery development	IEA	biological process
GO:0021503	neural fold bending	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003281	ventricular septum development	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray