|
Gene id |
7295 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
TXN Gene UCSC Ensembl |
|
Aliases |
TRDX, TRX, TRX1 |
|
Gene name |
thioredoxin |
|
Alternate names |
thioredoxin, ADF, ATL-derived factor, SASP, TXN delta 3, surface-associated sulphydryl protein, testicular tissue protein Li 199, thioredoxin delta 3, |
|
Gene location |
9q31.3 (110256506: 110243809) Exons: 5 NC_000009.12
|
|
Gene summary(Entrez) |
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. Th
|
|
OMIM |
187700 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04621 | NOD-like receptor signaling pathway | | hsa05418 | Fluid shear stress and atherosclerosis | |
|
| Associated diseases |
References |
| Cancer | GAD: 16424062 |
| Gonad development | INFBASE: 15120973 |
| Male factor infertility | MIK: 15538295 |
| Endometriosis | INFBASE: 25376627 |
| Asthenozoospermia | MIK: 29305108 |
| Male infertility | MIK: 29305108 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29305108 |
Asthenozoo
spermia, M
ale infert
ility
|
|
|
80 (40 asthenoz
oospermia, 40 n
ormozoospermia)
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
|