• Gene id: 727851

Gene Summary

• Gene Symbol: RGPD8   Gene   UCSC   Ensembl
• Aliases: RANBP2L1, RGP8, RanBP2alpha
• Gene name: RANBP2 like and GRIP domain containing 8
• Alternate names: RANBP2-like and GRIP domain-containing protein 8, RAN binding protein 2-like 1, ran-binding protein 2-like 3, ranBP2-like 3, ranBP2L3,
• Gene location: 2q14.1 (112433644: 112368368)     Exons: 27     NC_000002.12
• OMIM: 608547

Protein Summary

• Protein general information: O14715  
  • Name: RANBP2 like and GRIP domain containing protein 8 (Ran binding protein 2 like 3) (RanBP2 like 3) (RanBP2L3)
  • Length: 1765  
  • Mass: 198993
• Sequence:

  MRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRFLGLLYELEEN
  TEKAVECYRRSVELNPTQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCEGEDGWNKL
  FDLIQSELYVRPDDVHVNIRLVELYRSTKRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDK
  SDWRATNTDLLLAYANLMLLTLSTRDVQENRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMYAGSLLLK
  MGQHGNNVQWRALSELAALCYLIAFQVPRPKIKLREGKAGQNLLEMMACDRLSQSGHMLLSLSRGKQDFLKEVVE
  TFANKIGQSALYDALFSSQSPKDTSFLGSDDIGKIDVQEPELEDLARYDVGAIRAHNGSLQHLTWLGLQWNSLPA
  LPGIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPFPVCKQLC
  TERQKSWWDAVCTLIHRKAVPGNLAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKYLQKTGSGLNSFYGQLEYI
  GRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAFESIK
  SVVSYWNLALIFHRKAEDIENDALSPEEQEECRNYLTKTRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVM
  QELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPETPPRWTEDRNSLLNMICQQVEAIKKEM
  QELKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKG
  SSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKREKPLENDTGLQAQDIRGRKKGRGVIFGQTSSTFTFADVA
  KSTSGEGFQFGKKDLNFKGFSGAGEKLFSSRYGKMANKANTSGDFEKDDDAYKTEDSDDIHFEPVVQMPEKVELV
  TGEEGEKVLYSQGVKLFRFDAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITTTMNLKPLSGS
  DRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSG
  LKDFKTFLTNDQTKVTEEENKGSGTGVAGASDTTIKPNAENTGPTLEWDNYDLREDALDDSVSSSSVHASPLASS
  PVRKNLFRFDESTTGSNFSFKSALSLSKSPAKLNQSGTSVGTDEESVVTQEEERDGQYFEPVVPLPDLVEVSSGE
  ENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERV
  WVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEEIT
  RERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSKPFAFGNSSATGSLFGFSFNA
  PLKSNNSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPTEESSINYTFKTPEKEPPLWHAEFT
  KEELVQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPG
  SERERLLPVINTMLQLSPEEKGKLAAVAQDEEENPSRSSG

• Structural information:
  • Protein Domains: (1036..117-)
    (/note="RanBD1-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00164-)
    (1333..146-)
    (/note="RanBD1-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00164-)
    (1702..175-)
    (/note="GRIP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU-)
  • Interpro: IPR032023  IPR000237  IPR011993  IPR000156  IPR013026   IPR011990  IPR019734  
  • Prosite: PS50913 PS50196 PS50005 PS50293
  • STRING: ENSP00000306637
• Other Databases: GeneCards:  RGPD8  Malacards:  RGPD8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006607	NLS-bearing protein import into nucleus	IBA	biological process
GO:0005643	nuclear pore	IBA	cellular component
GO:0008536	Ran GTPase binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0005096	GTPase activator activity	IBA	contributes to
GO:0046907	intracellular transport	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0005643	nuclear pore	NAS	cellular component
GO:0008536	Ran GTPase binding	NAS	molecular function
GO:0008150	biological_process	ND	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq