• Gene id: 7128

Gene Summary

• Gene Symbol: TNFAIP3   Gene   UCSC   Ensembl
• Aliases: A20, AISBL, OTUD7C, TNFA1P2
• Gene name: TNF alpha induced protein 3
• Alternate names: tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, putative DNA-binding protein A20, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha induced protein 3, zinc finger protein A20,
• Gene location: 6q23.3 (137866316: 137883311)     Exons: 13     NC_000006.12
• Gene summary(Entrez): This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well a
• OMIM: 191163

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa04064	NF-kappa B signaling pathway
hsa04668	TNF signaling pathway
hsa04217	Necroptosis
hsa04621	NOD-like receptor signaling pathway
hsa04657	IL-17 signaling pathway
hsa05162	Measles
hsa05169	Epstein-Barr virus infection
hsa04217	Necroptosis
hsa04621	NOD-like receptor signaling pathway
hsa05169	Epstein-Barr virus infection
hsa04668	TNF signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa05162	Measles
hsa04657	IL-17 signaling pathway

Diseases

Associated diseases	References
Cancer (ovarian)	GAD: 20628624
Atherosclerosis	GAD: 19948975
Celiac disease	GAD: 20190752
Rheumatoid arthritis	GAD: 18794853
Multiple sclerosis	GAD: 19879194
Systemic lupus erythematosus (SLE)	GAD: 18677310
Chronic ulcerative colitis	GAD: 20176734
Diabetes	GAD: 19110536
Alzheimer's disease	GAD: 19141999
Highly overexpressed in cryptorchid samples	MIK: 18687424
Wegener granulomatosis	GAD: 20049410
Systemic sclerosis	KEGG: H01492
Cryptorchidism	MIK: 18687424
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
18687424	Highly overexpressed in cryptorchid samples			22 (10 control patients and 12 cryptorchid males (8 unilateral, 4 bilateral))	Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray