|
Gene id |
706 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
TSPO Gene UCSC Ensembl |
|
Aliases |
BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18 |
|
Gene name |
translocator protein |
|
Alternate names |
translocator protein, benzodiazepine peripheral binding site, mitochondrial benzodiazepine receptor, peripheral-type benzodiazepine receptor, |
|
Gene location |
22q13.2 (43151558: 43163241) Exons: 5 NC_000013.11
|
|
Gene summary(Entrez) |
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholestero
|
|
OMIM |
109610 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04080 | Neuroactive ligand-receptor interaction | | hsa04979 | Cholesterol metabolism | | hsa05166 | Human T-cell leukemia virus 1 infection | | hsa05166 | Human T-cell leukemia virus 1 infection | | hsa04080 | Neuroactive ligand-receptor interaction | | hsa04979 | Cholesterol metabolism | |
|
| Associated diseases |
References |
| Cancer (lung) | GAD: 19170196 |
| Cancer (bladder) | GAD: 19692168 |
| Bipolar disorder | GAD: 11304832 |
| Panic disorder | GAD: 16511838 |
| Autism | GAD: 19598235 |
| Mood disorders | GAD: 11304832 |
| Schizophrenia | GAD: 11215759 |
| Chronic renal failure | GAD: 21085059 |
| Germ cell development | MIK: 27608010 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Germ cell development | MIK: 27608010 |
| Spermatogenic defects | MIK: 31037746 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 27608010 |
Germ cell
developmen
t
|
|
|
|
Male infertility |
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|