• Gene id: 7059

Gene Summary

• Gene Symbol: THBS3   Gene   UCSC   Ensembl
• Aliases: TSP3
• Gene name: thrombospondin 3
• Alternate names: thrombospondin-3,
• Gene location: 1q22 (155209179: 155195587)     Exons: 25     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfid
• OMIM: 190120

Protein Summary

• Protein general information: P49746  
  • Name: Thrombospondin 3
  • Length: 956  
  • Mass: 104201
• Sequence:

  METQELRGALALLLLCFFTSASQDLQVIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLSTFRLPPKQGGVLFGL
  YSRQDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQ
  HAGLPALAPIPPAEVDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALHSILG
  EQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRGVDCMEVYEYPGYRC
  GPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECN
  DGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG
  NGNVCGTDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNK
  DQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDS
  CPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPG
  PDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLN
  QGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAV
  AQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQL
  VADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV

• Structural information:
  • Protein Domains: (23..19-)
    (/note="Laminin-G-like)
    (316..35-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (370..41-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (-)
  • Interpro: IPR013320  IPR001881  IPR013032  IPR000742  IPR018097   IPR001791  IPR024665  IPR028507  IPR003367  IPR017897  IPR008859  IPR028974  
  • Prosite: PS01186 PS50026 PS01187 PS51234 PS51236
  • STRING: ENSP00000357362
• Other Databases: GeneCards:  THBS3  Malacards:  THBS3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0062023	collagen-containing extracellular matrix	IBA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0008201	heparin binding	IEA	molecular function
GO:0007155	cell adhesion	IEA	biological process
GO:0008201	heparin binding	IDA	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0003417	growth plate cartilage development	IEA	biological process
GO:0060346	bone trabecula formation	IEA	biological process
GO:0043931	ossification involved in bone maturation	IEA	biological process
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0007160	cell-matrix adhesion	NAS	biological process
GO:0005509	calcium ion binding	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04510	Focal adhesion
hsa04145	Phagosome
hsa04512	ECM-receptor interaction
hsa05144	Malaria

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq