• Gene id: 7058

Gene Summary

• Gene Symbol: THBS2   Gene   UCSC   Ensembl
• Aliases: TSP2
• Gene name: thrombospondin 2
• Alternate names: thrombospondin-2,
• Gene location: 6q27 (169253845: 169215784)     Exons: 22     NC_000006.12
• Gene summary(Entrez): The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor gr
• OMIM: 188062

Protein Summary

• Protein general information: P35442  
  • Name: Thrombospondin 2
  • Length: 1172  
  • Mass: 129991
  • Tissue specificity: High expression in invertebral disk tissue. {ECO
• Sequence:

  MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADDLSKIT
  KIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLEDVGLADSQWK
  NVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKG
  CQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND
  NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCL
  HSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCS
  VTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPE
  PQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI
  CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPM
  YKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVT
  DEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRD
  TDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD
  DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQI
  DPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW
  EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRV
  LVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI

• Structural information:
  • Protein Domains: (19..21-)
    (/note="Laminin-G-like)
    (318..37-)
    (/note="VWFC-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00220-)
    (381..43-)
    1 (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00210-)
    (437..49-)
    2 (/note="TSP-type-1)
    (-)
  • Interpro: IPR013320  IPR001881  IPR013032  IPR000742  IPR024731   IPR001791  IPR003367  IPR017897  IPR008859  IPR000884  IPR036383  IPR015455  IPR028974  IPR001007  
  • Prosite: PS01186 PS50026 PS50092 PS51234 PS51236 PS01208 PS50184
  • PDB: 1YO8 2RHP
  • PDBsum: 1YO8 2RHP
  • STRING: ENSP00000355751
• Other Databases: GeneCards:  THBS2  Malacards:  THBS2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016525	negative regulation of angiogenesis	IBA	biological process
GO:0062023	collagen-containing extracellular matrix	IBA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016525	negative regulation of angiogenesis	IEA	biological process
GO:0007155	cell adhesion	IEA	biological process
GO:0007155	cell adhesion	IEA	biological process
GO:0008201	heparin binding	IEA	molecular function
GO:0008201	heparin binding	TAS	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016525	negative regulation of angiogenesis	IEA	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0016525	negative regulation of angiogenesis	IEA	biological process
GO:0005604	basement membrane	IEA	cellular component
GO:0051965	positive regulation of synapse assembly	IEA	biological process
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005576	extracellular region	HDA	cellular component
GO:0031091	platelet alpha granule	IDA	cellular component
GO:0016525	negative regulation of angiogenesis	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa04510	Focal adhesion
hsa04145	Phagosome
hsa04512	ECM-receptor interaction
hsa05144	Malaria

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq