|
Gene id |
6929 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
TCF3 Gene UCSC Ensembl |
|
Aliases |
AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, p75 |
|
Gene name |
transcription factor 3 |
|
Alternate names |
transcription factor E2-alpha, NOL1-TCF3 fusion, VDR interacting repressor, class B basic helix-loop-helix protein 21, helix-loop-helix protein HE47, immunoglobulin transcription factor 1, kappa-E2-binding factor, negative vitamin D response element-binding prot, |
|
Gene location |
19p13.3 (1652614: 1609291) Exons: 21 NC_000001.11
|
|
Gene summary(Entrez) |
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodi
|
|
OMIM |
147141 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
| Pathway id | Pathway name |
|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | | hsa05202 | Transcriptional misregulation in cancer | | hsa05166 | Human T-cell leukemia virus 1 infection | | hsa05166 | Human T-cell leukemia virus 1 infection | | hsa05202 | Transcriptional misregulation in cancer | | hsa04550 | Signaling pathways regulating pluripotency of stem cells | |
|
| Associated diseases |
References |
| B-cell acute lymphoblastic leukemia | KEGG: H00001 |
| Spermatogenesis defects | MIK: 26753906 |
| Cryptorchidism | MIK: 28606200 |
| Male infertility | MIK: 26753906 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 26753906 |
Regulation
of sperma
togenesis,
Male infe
rtility
|
|
|
27 patients wit
h obstructive a
zoospermia
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
|