• Gene id: 6898

Gene Summary

• Gene Symbol: TAT   Gene   UCSC   Ensembl
• Gene name: tyrosine aminotransferase
• Alternate names: tyrosine aminotransferase, L-tyrosine:2-oxoglutarate aminotransferase, testis tissue sperm-binding protein Li 34a, tyrosine aminotransferase, cytosolic,
• Gene location: 16q22.2 (71577091: 71565659)     Exons: 12     NC_000016.10
• Gene summary(Entrez): This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome)
• OMIM: 605015

Protein Summary

• Protein general information: P17735  
  • Name: Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L tyrosine:2 oxoglutarate aminotransferase)
  • Length: 454  
  • Mass: 50399
• Sequence:

  MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMIS
  LSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDL
  CLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVF
  SKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
  FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLM
  VGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQE
  ECDK

• Structural information:
  • Interpro: IPR004839  IPR004838  IPR015424  IPR015422  IPR015421   IPR011715  IPR005958  IPR005957  
  • Prosite: PS00105
  • PDB: 3DYD
  • PDBsum: 3DYD
  • STRING: ENSP00000348234
• Other Databases: GeneCards:  TAT  Malacards:  TAT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006103	2-oxoglutarate metabolic process	IDA	biological process
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IDA	molecular function
GO:0006572	tyrosine catabolic process	IDA	biological process
GO:0006536	glutamate metabolic process	IDA	biological process
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IEA	molecular function
GO:0009058	biosynthetic process	IEA	biological process
GO:0009074	aromatic amino acid family catabolic process	IEA	biological process
GO:0030170	pyridoxal phosphate binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0006520	cellular amino acid metabolic process	IEA	biological process
GO:0008483	transaminase activity	IEA	molecular function
GO:0009072	aromatic amino acid family metabolic process	IEA	biological process
GO:0006559	L-phenylalanine catabolic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0006572	tyrosine catabolic process	IEA	biological process
GO:0008483	transaminase activity	IEA	molecular function
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006559	L-phenylalanine catabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0046689	response to mercury ion	IEA	biological process
GO:0016597	amino acid binding	IEA	molecular function
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IEA	molecular function
GO:0006103	2-oxoglutarate metabolic process	IEA	biological process
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	IEA	molecular function
GO:0006979	response to oxidative stress	IEA	biological process
GO:0006520	cellular amino acid metabolic process	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0006572	tyrosine catabolic process	IEA	biological process
GO:0006536	glutamate metabolic process	IEA	biological process
GO:0006559	L-phenylalanine catabolic process	IEA	biological process
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	NAS	molecular function
GO:0005575	cellular_component	ND	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01230	Biosynthesis of amino acids
hsa00270	Cysteine and methionine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis

Diseases

Associated diseases	References
Tyrosinemia	KEGG:H00165
Tyrosinemia	KEGG:H00165
Tyrosinemia	PMID:1357662
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881