|
Gene id |
6790 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
AURKA Gene UCSC Ensembl |
|
Aliases |
AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7 |
|
Gene name |
aurora kinase A |
|
Alternate names |
aurora kinase A, aurora 2, aurora/IPL1-like kinase, aurora/IPL1-related kinase 1, breast tumor-amplified kinase, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase , |
|
Gene location |
20q13.2 (56392336: 56369388) Exons: 12 NC_000020.11
|
|
Gene summary(Entrez) |
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cel
|
|
OMIM |
603072 |
|
| Pathway id | Pathway name |
|---|
| hsa04114 | Oocyte meiosis | | hsa04914 | Progesterone-mediated oocyte maturation | |
|
| Associated diseases |
References |
| Cancer | GAD: 17908995 |
| Colon cancer | OMIM: 603072 |
| Endometriosis | INFBASE: 21840910 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Role in spermatogenesis, sperm motility | MIK: 29842884 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29842884 |
Role in sp
ermatogene
sis, sperm
motility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|