• Gene id: 6578

Gene Summary

• Gene Symbol: SLCO2A1   Gene   UCSC   Ensembl
• Aliases: MATR1, OATP2A1, PGT, PHOAR2, SLC21A2
• Gene name: solute carrier organic anion transporter family member 2A1
• Alternate names: solute carrier organic anion transporter family member 2A1, matrin F/G 1, solute carrier family 21 (prostaglandin transporter), member 2,
• Gene location: 3q22.1-q22.2 (134029954: 133932700)     Exons: 16     NC_000003.12
• Gene summary(Entrez): This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, D
• OMIM: 607506

Protein Summary

• Protein general information: Q92959  
  • Name: Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)
  • Length: 643  
  • Mass: 70044
  • Tissue specificity: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. {ECO
• Sequence:

  MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISS
  LNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDL
  PPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLL
  GSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE
  EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPA
  AALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSC
  PDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFV
  SLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND
  ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI

• Structural information:
  • Protein Domains: (438..49-)
    (/note="Kazal-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798"-)
  • Interpro: IPR002350  IPR036058  IPR020846  IPR036259  IPR004156  
  • Prosite: PS51465 PS50850
  • PDB: 3MRR
  • PDBsum: 3MRR
  • STRING: ENSP00000311291
• Other Databases: GeneCards:  SLCO2A1  Malacards:  SLCO2A1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015347	sodium-independent organic anion transmembrane transporter activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0015132	prostaglandin transmembrane transporter activity	IBA	molecular function
GO:0015732	prostaglandin transport	IBA	biological process
GO:0043252	sodium-independent organic anion transport	IBA	biological process
GO:0022857	transmembrane transporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005319	lipid transporter activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006869	lipid transport	TAS	biological process
GO:0016020	membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0015132	prostaglandin transmembrane transporter activity	TAS	molecular function
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0015732	prostaglandin transport	IEA	biological process
GO:0015132	prostaglandin transmembrane transporter activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Primary hypertrophic osteoarthropathy	KEGG:H00457
Primary hypertrophic osteoarthropathy	KEGG:H00457
Chronic nonspecific multiple ulcers of the small intestine	KEGG:H01853
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881