• Gene id: 65083

Gene Summary

• Gene Symbol: NOL6   Gene   UCSC   Ensembl
• Aliases: NRAP, UTP22, bA311H10.1
• Gene name: nucleolar protein 6
• Alternate names: nucleolar protein 6, nucleolar RNA-associated protein, nucleolar protein 6 (RNA-associated), nucleolar protein family 6 (RNA-associated),
• Gene location: 9p13.3 (33473942: 33460810)     Exons: 26     NC_000009.12
• Gene summary(Entrez): The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of

Protein Summary

• Protein general information: Q9H6R4  
  • Name: Nucleolar protein 6 (Nucleolar RNA associated protein) (Nrap)
  • Length: 1146  
  • Mass: 127593
• Sequence:

  MGPAPAGEQLRGATGEPEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRET
  EILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKG
  CFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCF
  SYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAGDGSPEPPTPRYNTW
  VLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVL
  RSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDS
  RADDGFHLLLMTPKPMIRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLL
  AHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREA
  VVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWG
  LEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMTVVCHLEGSGQWPQD
  AEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASL
  RLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGF
  LRFLFLVSTFDWKNNPLFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVV
  LAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVL
  GYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILED
  FAVLGEGLVQTVEARSERWTV

• Structural information:
  • Interpro: IPR005554  IPR035082  IPR035367  IPR035368  IPR035369   IPR035370  IPR035371  
  • STRING: ENSP00000297990
• Other Databases: GeneCards:  NOL6  Malacards:  NOL6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0034456	UTP-C complex	IBA	cellular component
GO:0032545	CURI complex	IBA	cellular component
GO:0032040	small-subunit processome	IBA	cellular component
GO:0006409	tRNA export from nucleus	IBA	biological process
GO:0006364	rRNA processing	IBA	biological process
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0006364	rRNA processing	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0000794	condensed nuclear chromosome	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0006364	rRNA processing	ISS	biological process
GO:0005730	nucleolus	ISS	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0005730	nucleolus	ISS	cellular component
GO:0000794	condensed nuclear chromosome	ISS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03008	Ribosome biogenesis in eukaryotes

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray