• Gene id: 643904

Gene Summary

• Gene Symbol: RNF222   Gene   UCSC   Ensembl
• Gene name: ring finger protein 222
• Alternate names: RING finger protein 222, RING finger protein LOC643904,
• Gene location: 17p13.1 (8397834: 8390701)     Exons: 4     NC_000017.11
• OMIM: 618599

Protein Summary

• Protein general information: A6NCQ9  
  • Name: RING finger protein 222
  • Length: 220  
  • Mass: 23767
• Sequence:

  MSEGESKDSSGSECPVCYEKFRDLEGASRTLSCGHVFCHDCLVKYLLSTRVDGQVQRTLVCPICRYVTFLSKKSS
  RWPSMLDKSSQTLAVPVGLPSVPPLDSLGHTNPLAASSPAWRPPPGQARPPGSPGQSAQLPLDLLPSLPRESQIF
  VISRHGMPLGEQDSVLPRRSLAELSEASLAPRSARAFCCRSRALLLITLIAVVAVVAAILPWVLLVRKQA

• Structural information:
  • Interpro: IPR042973  IPR027370  IPR001841  IPR013083  IPR017907  
  • Prosite: PS00518 PS50089
  • STRING: ENSP00000382330
• Other Databases: GeneCards:  RNF222  Malacards:  RNF222

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray