• Gene id: 64318

Gene Summary

• Gene Symbol: NOC3L   Gene   UCSC   Ensembl
• Aliases: AD24, C10orf117, FAD24
• Gene name: NOC3 like DNA replication regulator
• Alternate names: nucleolar complex protein 3 homolog, NOC3 protein homolog, NOC3L DNA replication regulator, factor for adipocyte differentiation 24, nucleolar complex associated 3 homolog, nucleolar complex-associated protein 3-like protein,
• Gene location: 10q23.33 (94362958: 94314906)     Exons: 23     NC_000010.11
• OMIM: 610769

Protein Summary

• Protein general information: Q8WTT2  
  • Name: Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3 like protein) (Nucleolar complex associated protein 3 like protein)
  • Length: 800  
  • Mass: 92548
  • Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus. {ECO
• Sequence:

  MKARRNKKQIPSFRKLIKTSKVKLENKLKNKQFKQQSTLKKYRKEQRKLRQAVKDAVSKKPIPLENPKEKRPGKR
  IEREEEEEEEALPLDMMDEDDLQLMKDLGQRVSFLTRDLSSSEPVHAKKRKHERIIDKYEKIPRTLQTAPEKELI
  HLLPIKDKSGIIPQTREKPVTDSNKDEEDQEEERELEEEIIEDPIQELTIEEHLIERKKKLQEKKMHIAALASAI
  LSDPENNIKKLKELRSMLMEQDPDVAVTVRKLVIVSLMELFKDITPSYKIRPLTEAEKSTKTRKETQKLREFEEG
  LVSQYKFYLENLEQMVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDMSK
  LISEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKKFMTF
  KEKRKSLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQRSPLLPAVLEGLAKF
  AHLINVEFFDDLLVVLHTLIESGDLSYQESLHCVQTAFHILSGQGDVLNIDPLKFYTHLYKTLFKLHAGATNEGV
  EIVLQCLDVMLTKRRKQVSQQRALAFIKRLCTLALHVLPNSSIGILATTRILMHTFPKTDLLLDSESQGSGVFLP
  ELDEPEYCNAQNTALWELHALRRHYHPIVQRFAAHLIAGAPSEGSGALKPELSRRSATELFEAYSMAEMTFNPPV
  ESSNPKIKGKFLQGDSFLNEDLNQLIKRYSSEVATESPLDFTKYLKTSLH

• Structural information:
  • Interpro: IPR016024  IPR005612  IPR011501  IPR016903  
  • STRING: ENSP00000360412
• Other Databases: GeneCards:  NOC3L  Malacards:  NOC3L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0003682	chromatin binding	IBA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0045444	fat cell differentiation	IEA	biological process
GO:0005730	nucleolus	IEA	cellular component
GO:0016607	nuclear speck	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0016607	nuclear speck	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)