• Gene id: 64118

Gene Summary

• Gene Symbol: DUS1L   Gene   UCSC   Ensembl
• Aliases: DUS1, PP3111
• Gene name: dihydrouridine synthase 1 like
• Alternate names: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like,
• Gene location: 17q25.3 (82065814: 82057505)     Exons: 9     NC_000017.11

Protein Summary

• Protein general information: Q6P1R4  
  • Name: tRNA dihydrouridine(16/17) synthase [NAD(P)(+)] like (EC 1.3.1. ) (tRNA dihydrouridine synthase 1 like)
  • Length: 473  
  • Mass: 53230
• Sequence:

  MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCEVCPEDRP
  LIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQDEWDLLQRMILLAHEKLSVPVTCKIRV
  FPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTG
  VQGVMSAEGNLHNPALFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEG
  IAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEEEEGGTEVLSKNKQKK
  QLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRASKETADCPGHGLLFKTKLEKSLAWKEAQPEL
  QEPQPAAPGTPGGFSEVMGSALA

• Structural information:
  • Interpro: IPR013785  IPR035587  IPR001269  IPR018517  
  • Prosite: PS01136
  • CDD: cd02801
  • STRING: ENSP00000346280
• Other Databases: GeneCards:  DUS1L  Malacards:  DUS1L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017150	tRNA dihydrouridine synthase activity	IBA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0017150	tRNA dihydrouridine synthase activity	IEA	molecular function
GO:0050660	flavin adenine dinucleotide binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0002943	tRNA dihydrouridine synthesis	IEA	biological process
GO:0002943	tRNA dihydrouridine synthesis	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq