• Gene id: 63923

Gene Summary

• Gene Symbol: TNN   Gene   UCSC   Ensembl
• Aliases: TN-W, TNW
• Gene name: tenascin N
• Alternate names: tenascin-N, TN-N, tenascin-W,
• Gene location: 1q25.1 (175067832: 175148074)     Exons: 20     NC_000001.11
• OMIM: 617472

Protein Summary

• Protein general information: Q9UQP3  
  • Name: Tenascin N (TN N) (Tenascin W) (TN W)
  • Length: 1299  
  • Mass: 144034
  • Tissue specificity: Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed
• Sequence:

  MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSHTYKIDVPKSALVQVDADPQPLSDDGASLLAL
  GEAREEQNIIFRHNIRLQTPQKDCELAGSVQDLLARVKKLEEEMVEMKEQCSAQRCCQGVTDLSRHCSGHGTFSL
  ETCSCHCEEGREGPACERLACPGACSGHGRCVDGRCLCHEPYVGADCGYPACPENCSGHGECVRGVCQCHEDFMS
  EDCSEKRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVTPQGLQLLKNTEDSLLVSWEPSSQVDHYLLSYYPLGK
  ELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTDLAVLGTAWVTDETENSLDVEWENPS
  TEVDYYKLRYGPMTGQEVAEVTVPKSSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTEIDSPTNVV
  TDRVTEDTATVSWDPVQAVIDKYVVRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKADT
  NALTEIDSPANLVTDRVTENTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHV
  WAQKGDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKYVVRYTSAGGETREVPVGKEQSSTVL
  TGLRPGMEYMVHVWAQKGDQESKKADTKAQTDIDSPQNLVTDRVTENMATVSWDPVRATIDRYVVRYTSAKDGET
  REVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGAQESKKADTKAQTDIDSPQNLVTDWVTENTATVSWDPVQATID
  RYVVHYTSANGETREVPVGKEQSSTVLTGLRPGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENM
  ATVSWDPVQATIDKYMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGAQESKKADTKAQTELDP
  PRNLRPSAVTQSGGILTWTPPSAQIHGYILTYQFPDGTVKEMQLGREDQRFALQGLEQGATYPVSLVAFKGGRRS
  RNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRPLQVYCDMETDGGGWIVFQRRNTGQLDFFKR
  WRSYVEGFGDPMKEFWLGLDKLHNLTTGTPARYEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGD
  ALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPYVELKIR
  PHGYSREPVLGRKKRTLRGRLRTF

• Structural information:
  • Protein Domains: (167..19-)
    (/note="EGF-like-1)
    (199..22-)
    (/note="EGF-like-2)
    (230..26-)
    (/note="EGF-like-3)
    (264..35-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (353..44-)
    (/note="Fibronectin-typ)
  • Interpro: IPR013032  IPR000742  IPR041161  IPR036056  IPR002181   IPR020837  IPR003961  IPR036116  IPR013783  
  • Prosite: PS00022 PS01186 PS00514 PS51406 PS50853
  • CDD: cd00063 cd00087
  • STRING: ENSP00000239462
• Other Databases: GeneCards:  TNN  Malacards:  TNN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005178	integrin binding	IBA	molecular function
GO:1990138	neuron projection extension	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0007160	cell-matrix adhesion	IBA	biological process
GO:0062023	collagen-containing extracellular matrix	IBA	cellular component
GO:1905240	negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation	ISS	biological process
GO:0033689	negative regulation of osteoblast proliferation	ISS	biological process
GO:0045668	negative regulation of osteoblast differentiation	ISS	biological process
GO:0002076	osteoblast development	ISS	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0045668	negative regulation of osteoblast differentiation	IEA	biological process
GO:0043025	neuronal cell body	IEA	cellular component
GO:0042802	identical protein binding	IEA	molecular function
GO:0009986	cell surface	IEA	cellular component
GO:0007409	axonogenesis	IEA	biological process
GO:0005178	integrin binding	IEA	molecular function
GO:0002076	osteoblast development	IEA	biological process
GO:1990026	hippocampal mossy fiber expansion	IEA	cellular component
GO:1905240	negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation	IEA	biological process
GO:0097442	CA3 pyramidal cell dendrite	IEA	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0033689	negative regulation of osteoblast proliferation	IEA	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0007160	cell-matrix adhesion	IEA	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:2001223	negative regulation of neuron migration	ISA	biological process
GO:0070593	dendrite self-avoidance	ISA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa05165	Human papillomavirus infection
hsa05206	MicroRNAs in cancer
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq